Senior Director, Clinical Development - RNAi Therapeutics

United States Digital Space LLC; Maidenhead; Hybrid; GBP 120,000 - 190,000; Full time

Job summary

Alnylam Pharmaceuticals is seeking a Senior Director, Clinical Research to provide clinical leadership in RNAi therapeutics across multiple programs, with primary focus on Huntington’s disease. The role involves guiding development strategies, ensuring trial oversight, and coordinating with Regulatory, Biostatistics, Medical Affairs and Commercial teams.

The position is hybrid, primarily located at our Cambridge, MA headquarters or Maidenhead, UK location, offering opportunities to influence

Qualifications

• MD with strong research background; board certification desirable; Huntington’s disease drug development experience favored.
• 10+ years of industry or clinical academic experience.
• Proven track record leading Phase 2/3 programs and regulatory interactions.
• Familiarity with clinical research concepts, trial design, biostatistics and regulatory practices.

Responsibilities

• Lead strategic clinical development programs across Huntington’s and other indications.
• Oversee trial conduct and safety, timelines, and deliverables.
• Collaborate with Regulatory, Biostatistics, Medical Affairs and Commercial to align product strategy.
• Represent Alnylam in external regulatory meetings and scientific conferences.
• Mentor teams and drive bench-to-bedside early phase programs.

Skills

MD/MD-PhD

Leadership

Education

Board Certification

Job description

Alnylam Pharmaceuticals is seeking a Senior Director, Clinical Research to provide clinical leadership in RNAi therapeutics across multiple programs, with primary focus on Huntington’s disease. The role involves guiding development strategies, ensuring trial oversight, and coordinating with Regulatory, Biostatistics, Medical Affairs and Commercial teams.

The position is hybrid, primarily located at our Cambridge, MA headquarters or Maidenhead, UK location, offering opportunities to influence