Senior Computational Chemist, LNP Design (Remote/Part-Time)

CureAge Therapeutics; Greater London; On-site; GBP 70,000 - 110,000; Full time

Job summary

CureAge Therapeutics is seeking a senior computational chemist to lead design of our lipid nanoparticle delivery platform for nucleic acid therapies. You will integrate chemical reasoning with AI-enabled tools to guide formulation choices and data-driven decisions.

Open to part-time or flexible arrangements for the right candidate. Joining a growing start-up, you will shape the scientific strategy, work with the founding team, and collaborate with the experimental group to translate

Qualifications

• MSc or PhD in Chemistry, Medicinal Chemistry, Computational Chemistry, Pharmaceutical Sciences, Biophysics, or a related discipline.
• Strong understanding of chemical structure–property relationships and physicochemical principles.
• Experience with LNPs, lipid-based drug delivery, or related formulation technologies.
• Experience applying computational chemistry, cheminformatics, or AI-assisted molecular design tools.
• Ability to integrate computational predictions with experimental evidence into actionable recommendations.
• Self-driven, analytical, and comfortable taking ownership in a small, fast-moving team.

Responsibilities

• Apply chemical and biophysical principles to optimise LNP composition and formulation parameters.
• Drive rational design of targeted LNPs to enhance delivery to specific cell types and tissues.
• Leverage AI-enabled chemistry tools and predictive models to identify promising components and modifications.
• Apply molecular modelling and simulation to inform decisions.
• Collaborate with experimental team to translate insights into tests and screening plans.
• Analyse results and iteratively refine formulation design.

Skills

Computational chemistry

Structure-property relationships

Molecular interactions

AI-enabled chemistry tools

Cheminformatics

Molecular modelling

DoE principles

Education

MSc/PhD in Chemistry or related field

Tools

Cheminformatics platforms

Molecular modelling tools

Molecular dynamics

Job description

CureAge Therapeutics is seeking a senior computational chemist to lead design of our lipid nanoparticle delivery platform for nucleic acid therapies. You will integrate chemical reasoning with AI-enabled tools to guide formulation choices and data-driven decisions.

Open to part-time or flexible arrangements for the right candidate. Joining a growing start-up, you will shape the scientific strategy, work with the founding team, and collaborate with the experimental group to translate