Senior Clinical Pharmacology Lead — MIDD & Modelling Expert

Roche; Welwyn; On-site; GBP 164,000 - 218,000; Full time

Job summary

Roche is seeking a senior Clinical Pharmacology professional to lead quantitative pharmacology efforts across development programs. You will apply MIDD to optimise trial design and dose selection, using tools like NONMEM and R to build predictive models.

The role spans small and large molecules, with responsibility for regulatory interactions and cross-functional collaboration on a truly global scale. You will mentor junior scientists, drive AI/ML innovations in CP, and partner with discovery,

Qualifications

• PhD/ PharmD/ MD with specialisation in Pharmacometrics or Clinical Pharmacology.
• 5+ years in Quantitative Clinical Pharmacology within pharma/biotech.
• Strong experience applying MIDD and predictive modelling.

Responsibilities

• Lead CP and MIDD strategies across development phases.
• Design and execute clinical trial simulations and PK/PD analyses.
• Drive regulatory submissions (IB/IND/NDA) with high-quality documents.
• Support business development through due diligence input.
• Incorporate AI/ML methods to enhance modelling workflows.
• Collaborate across a global matrix to align strategy.

Skills

Pharmacometric modelling

Clinical pharmacology

MIDD approaches

Regulatory submission

Cross-functional leadership

Education

PhD/PharmD/MD in Pharmacometrics or Clinical Pharmacology

Tools

NONMEM

R

SimCyp

MATLAB

Job description

Roche is seeking a senior Clinical Pharmacology professional to lead quantitative pharmacology efforts across development programs. You will apply MIDD to optimise trial design and dose selection, using tools like NONMEM and R to build predictive models.

The role spans small and large molecules, with responsibility for regulatory interactions and cross-functional collaboration on a truly global scale. You will mentor junior scientists, drive AI/ML innovations in CP, and partner with discovery,