Scientist, Discovery & Translational Research

Alnylam Pharmaceuticals; Cambridge; On-site; GBP 40,000 - 80,000; Full time

Job summary

An innovative firm is seeking a passionate Scientist to join a multidisciplinary team focused on drug discovery and translational research. This role involves identifying and validating novel drug targets, leading the development process from concept to clinic. The ideal candidate will have a PhD in biology, strong organizational skills, and a passion for lab work. Join a company recognized for its commitment to innovation and inclusivity, where your contributions will help transform lives through groundbreaking RNAi therapeutics.

Qualifications

• PhD in biology or related field is essential.
• Postdoctoral experience or relevant experience preferred.

Responsibilities

• Identify and validate novel drug targets across various indications.
• Design and execute experiments in animal and in vitro models.
• Mentor junior scientists and communicate results with stakeholders.

Skills

Human Genetics

Multi-Omics

Proof-of-Concept Experiments

Mammalian Disease Models

Interpersonal Skills

Education

PhD in Biology

Postdoctoral Experience

Job description

Summary

Overview

The Discovery and Translational Research group at Alnylam is seeking a motivated and knowledgeable Scientist in the early target space. This individual will join a multidisciplinary team that identifies, validates, and develops drug candidates from idea to clinic. Responsibilities include identifying and validating novel drug targets across various indications and leading the Lead development process.

This position is onsite and will be primarily located in Cambridge, MA.

Job Description

Key Responsibilities

1. Work closely with Alnylam's human genetics, multi-omics, platform, and clinical teams to identify promising novel targets.
2. Contribute to target identification efforts based on human genetics, literature, academic collaborations, genomic approaches, etc.
3. Design and execute proof-of-concept experiments in animal and in vitro disease models.
4. Design studies, coordinate activities, and lead research from the bench.
5. Oversee lead discovery activities for selecting drug candidates for further development.
6. Develop assays to monitor target engagement and pharmacodynamic responses.
7. Collaborate with multifunctional teams to shepherd drug candidates through lead selection and development to the clinic.
8. Manage relationships with CROs and academic collaborators, including developing research plans and analyzing data.
9. Mentor junior scientists.
10. Communicate results with key stakeholders throughout the organization.

Qualifications

• PhD in biology or a biomedical sciences-related field.
• Postdoctoral experience or 1-2 years of relevant experience preferred.
• Strong publication record.
• Individuals with expertise in muscle biology, muscle metabolism, or metabolic disease are strongly encouraged to apply.
• Experience with disease biology and mammalian disease models is preferred.
• Solid organizational skills and ability to multitask are essential.
• Strong interpersonal and communication skills, teamwork experience, interest in learning new biology, and passion for lab work are important.

About Alnylam: Alnylam Pharmaceuticals (Nasdaq: ALNY) has pioneered RNA interference (RNAi) therapeutics, transforming lives through innovative medicines targeting genetic and other diseases. Founded in 2002, Alnylam continues to lead the RNAi revolution, translating scientific advances into real treatments.

Our culture: Our people-first culture is guided by core values: innovation, openness, purposefulness, excellence, and commitment. Recognized globally as a top employer, we foster an inclusive environment where employees can bring their authentic selves, feel valued, and reach their full potential. We are committed to equal employment opportunity and diversity, welcoming applicants regardless of race, religion, gender, or other protected characteristics.