Research Fellow in Host Pathogen Interactions

Leeds; Leeds; On-site; GBP 40,000 - 65,000; Full time

Benefits offered by this job

26 days annual leave + bank holidays (

Pension scheme including life cover

On-site gym The Edge membership

Staff development courses

On-site childcare & discounts

Travel discounts

Job summary

The University of Leeds invites applications for a molecular and cell biologist to study bunyavirus host-pathogen interactions within an international collaboration spanning virology, immunology, structural biology, and advanced image analysis.

You will employ genome-wide CRISPR-Cas9 and haploid cell screening, followed by mechanistic studies using imaging and functional manipulation, building on a strong publication record in high-impact journals.

Qualifications

• PhD in host-pathogen interactions or closely related field.
• Postdoctoral experience in genome-wide screening and molecular imaging.
• Proven publication record in high-ranking journals.

Responsibilities

• Study host-pathogen interactions of bunyaviruses in host cells at molecular and atomic level using genome-wide CRISPR-Cas9 and screening.
• Collaborate with virology, immunology, structural biology and imaging groups across an international project.

Skills

Host-pathogen interactions

Genome-wide screening

Molecular biology

Cell imaging techniques

Publication record

Education

PhD in a relevant field

Tools

CRISPR-Cas9

Haploid cell screening

Imaging analysis

Job description

We have a vacancy for a molecular and cell biologist to study the host-pathogen interactions of a group of viruses known as the bunyaviruses. This appointment is part of an international collaboration involving scientists working in virology, immunology, structural biology, and cutting-edge image analysis. We seek to understand the formation of viral factories by bunyaviruses within host cells at the molecular and atomic level. One specific goal of the project will be to use genome-wide screening and proteomic approaches to define host restriction factors and molecular components essential for the viral life cycle. The work will involve the implementation of genome-wide CRISPR-Cas9, and haploid cell screening followed by mechanistic dissection via imaging and functional manipulation.

You should have a PhD and post doctorial experience, in host pathogen-interactions, genome-wide screening, molecular biology and cell imaging techniques, as well as a proven publication record in high-ranking journals. The successful candidate will join the thriving research environment within the Faculty of Health and Life Sciences, and have the opportunity to use and gain experience of new state-of-the-art research facilities in cell biology, molecular virology and cell imaging.

Are you an ambitious researcher looking for your next challenge? Do you have an established background in host pathogen interactions and genomic screening? Do you want to further your career in one of the UKs leading research intensive Universities?

• 26 days holiday plus approx.16 Bank Holidays/days that the University is closed by custom (including Christmas) - That's 42 days a year!
• Generous pension scheme options plus life assurance.
• Health and Wellbeing: Discounted staff membership options at The Edge, our state-of-the-art Campus gym, with a pool, sauna, climbing wall, cycle circuit, and sports halls.
• Personal Development: Access to courses run by our Organisational Development & Professional Learning team.
• Access to on-site childcare, shopping discounts and travel schemes are also available.
• And much more!