Research Associate: iPSC Neuron Models for FA

The University of Sheffield; Sheffield; Vor Ort; GBP 36.000 - 48.000; Vollzeit

Benefits dieser Stelle

Flexible working opportunities

Annual leave entitlement

Pensions scheme

Staff discounts

Career development and mentoring

Zusammenfassung

The University of Sheffield seeks a Research Associate to support Friedreich’s ataxia research within SITraN. You will develop and characterise human iPSC-derived neuronal models, apply ICC, imaging, RNA sequencing and electrophysiology, and contribute to data analysis and publications.

You will work in a multidisciplinary team, plan experiments, optimise protocols and help progress funding applications. A PhD in neuroscience or related field is essential.

Qualifikationen

• PhD in Neuroscience or related subject is essential.
• Experience with human iPSC models and neuronal differentiation is required.
• Proven ability to lead projects and work in a collaborative team.
• Experience with ICC, fluorescence microscopy, RNA extraction or sequencing is preferred.
• Experience with patch-clamp electrophysiology is desirable.

Aufgaben

• Plan, conduct and interpret a programme of experimental research into FA mechanisms and therapeutics.
• Develop iPSC-derived neuronal models and differentiate iPSCs into relevant cell types.
• Optimize protocols, troubleshoot challenges and integrate datasets.
• Apply ICC, microscopy, molecular biology, RNA analysis and sequencing methods.
• Maintain accurate records and contribute to publications and funding applications.
• Provide guidance to students and junior researchers in techniques.

Kenntnisse

iPSC technology

Neuronal differentiation

Immunocytochemistry

Fluorescence microscopy

RNA sequencing

Patch-clamp electrophysiology

Data analysis

Scientific reporting

Ausbildung

PhD in Neuroscience or related subject

Tools

iPSC culture techniques

Patch-clamp setup

Fluorescence microscopy equipment

Jobbeschreibung

The University of Sheffield seeks a Research Associate to support Friedreich’s ataxia research within SITraN. You will develop and characterise human iPSC-derived neuronal models, apply ICC, imaging, RNA sequencing and electrophysiology, and contribute to data analysis and publications.

You will work in a multidisciplinary team, plan experiments, optimise protocols and help progress funding applications. A PhD in neuroscience or related field is essential.