Research Associate in vivo imaging

The University of Manchester; Manchester; On-site; GBP 42,000 - 54,000; Full time

Benefits offered by this job

Generous pension

25 days annual leave

EV car scheme

Job summary

The University of Manchester is seeking a Research Associate with expertise in pre-clinical in vivo cerebrovascular imaging to join the Microvascular@Manchester group.

The post holder will work under senior investigators in the Division of Cardiovascular Sciences and the Geoffrey Jefferson Brain Research Centre, focusing on cerebral blood flow and neurovascular mechanisms in mouse models relevant to dementia.

Qualifications

• Experience with preclinical vascular imaging techniques.
• Experience with behavioural assessment and physiological analysis.
• Strong analytical and experimental skills.

Responsibilities

• Lead in vivo imaging studies to assess pial artery function, vascular calcium signaling and cerebral blood flow in mouse models.
• Perform behavioural assessments, histology, immunohistochemistry and physiological analyses.
• Publish and present results; develop collaborations; contribute to grant applications within The University of Manchester.

Skills

In vivo imaging

Vascular physiology

Neurovascular coupling

Mouse models

Experimental skills

Education

PhD in neuroscience/biomedical sciences

Tools

Multiphoton microscopy

Optical imaging

Histology

Immunohistochemistry

Job description

This is an outstanding opportunity for a Research Associate with expertise in pre-clinical in-vivo cerebrovascular imaging, vascular physiology or neurovascular coupling to join the Microvascular@Manchester group under the supervision of Adam Greenstein, Ingo Schiessl, Kira Shaw and Harry Pritchard. The post holder will be based within the Division of Cardiovascular Sciences and the Geoffrey Jefferson Brain Research Centre at the University of Manchester.

The position is funded through the Manchester NaVigate Partnership, a major collaborative programme investigating how impaired cerebral blood flow contributes to cognitive decline and dementia. The project will determine how vascular amyloid-β(1-40) alters vascular smooth muscle calcium signaling, arterial constriction and cerebral blood flow, and whether these mechanisms can be targeted therapeutically.

The successful candidate will lead studies using state-of-the-art pre- clinical in vivo imaging approaches, including multiphoton microscopy and optical imaging methods, to assess pial artery function, vascular smooth muscle calcium signaling and cerebral blood flow in mouse models relevant to Alzheimer’s disease. Complementary approaches will include behavioural assessment, histology, immunohistochemistry and physiological analysis.

This position offers an excellent opportunity for an ambitious and highly motivated researcher to lead an exciting translational project within a multidisciplinary academic-industry collaboration. The ideal candidate will have strong experimental and analytical skills, experience in preclinical vascular imaging, and a passion for understanding mechanisms underlying neurovascular dysfunction in dementia. The successful applicant will have opportunities to publish, present internationally, develop collaborations and contribute to future grant applications within The University of Manchester.

(Grades 6-9)

Our benefits include:

• Generous employer contribution pension
• 29 days annual leave plus bank holidays, along with Christmas closure
• Ride to work and EV car scheme available

For more information, please see University of Manchester Benefits. You can also find information on our Flexible and Hybrid working here.

We are an open place of enquiry and challenge. We embrace and celebrate difference, diversity and debate, and we pride ourselves on being a place of education, learning and community where we are able, within the law, to question and test received wisdom, express new ideas and explore controversial or unpopular topics and opinions. Find out more from our Freedom of Speech Policy.

Successful candidates may be subject to pre-employment screening carried out on our behalf by a third party. The offer of employment will be dependent on the successful candidate passing that screening. Whilst you will be required to provide express consent at a later stage, by continuing with your application now you acknowledge that you are aware that such screening will take place, and agree to take part in the process.

Enquiries About The Role, Shortlisting And Interviews

Name: Dr. Ingo Schiessl

Email: [e-mail]

General enquiries and administrative support

[e-mail]

Technical and job portal support

https://jobseekersupport.jobtrain.co.uk/support/home

Applications close at midnight on the closing date.

Please see Further Particulars and Person Specification below