Rare-Disease Medical Ethics Manager (Signatory)

AstraZeneca / Alexion; Camden Town; On-site; GBP 90,000 - 115,000; Full time

Job summary

AstraZeneca / Alexion is seeking a Medical Ethics Manager to support its UK & Ireland Rare Disease portfolio. As a Nominated Signatory, you will guide compliant, patient-centred activities and oversee ethical review processes with human oversight of AI-enabled tools.

You will provide evidence-based advice, strengthen governance and collaborate with cross-functional teams to ensure ABPI compliance and UK regulatory alignment across Medicines Affordability, Medical Affairs and Signatory functions.

Qualifications

• Registered physician or pharmacist eligible to act as a Nominated Signatory.
• Experience in Medical Affairs, medical review, signatory work or pharmaceutical compliance.
• Strong working knowledge of the ABPI Code and UK requirements.
• Clear communication and effective cross-functional partnering.

Responsibilities

• Review and approve materials as a Nominated Signatory, applying ABPI/IPHA Codes and Alexion standards.
• Advise cross-functional partners on medical ethics and compliance questions; escalate high-risk matters.
• Maintain review procedures, checklists and controls; support training and continuous improvement.
• Use approved digital tools to improve review quality and turnaround; protect confidential data.
• Monitor data and identify improvements; provide updates to Medical Ethics Lead.

Skills

Medical ethics

Signatory experience

Cross-functional partnering

Strong communication

Education

Medical degree (MD/MBBS) or Pharmacist qualification

Tools

AI-enabled review tools

ABPI Code knowledge

Job description

AstraZeneca / Alexion is seeking a Medical Ethics Manager to support its UK & Ireland Rare Disease portfolio. As a Nominated Signatory, you will guide compliant, patient-centred activities and oversee ethical review processes with human oversight of AI-enabled tools.

You will provide evidence-based advice, strengthen governance and collaborate with cross-functional teams to ensure ABPI compliance and UK regulatory alignment across Medicines Affordability, Medical Affairs and Signatory functions.