Rare Disease Medical Ethics Lead | Signatory & AI Tools

Alexion; Greater London; On-site; GBP 80,000 - 110,000; Full time

Job summary

Alexion in London seeks a Medical Ethics Manager to enable patient-centered activities while ensuring compliance with ABPI/IPHA Codes. You will act as a Nominated Signatory, oversee signatory processes, and drive governance, training and continuous improvement across UK & Ireland Rare Disease.

You will use approved AI-enabled tools with robust human oversight to enhance review quality, maintain confidential information, and collaborate with Digital/Ops, Privacy, Legal and Compliance teams.

Qualifications

• Registered Physician or Pharmacist eligible to act as a Nominated Signatory.
• Experience in Medical Affairs, medical review, signatory, compliance or related pharma role.
• Experience managing processes, competing priorities and cross-functional stakeholders.
• Ability to use approved digital or AI-enabled tools responsibly, validate outputs and protect confidential information.
• Strong ethical judgement and evidence-based decision making.
• Deep knowledge of ABPI Code and UK pharma requirements.
• Strong analytical and critical-thinking skills evaluating evidence, claims and risk.
• Clear written and verbal communication for varied audiences.
• Effective stakeholder partnering, influencing and challenge across teams.
• Strong organisation and attention to detail in high-volume, deadline-driven environments.
• Learning agility and curiosity about rare disease and evolving standards.
• Digital and data literacy with responsible AI use and validation.

Responsibilities

• Deliver medical ethics and Code support for Alexion UK & Ireland Rare Disease.
• Act as Nominated Signatory for materials and activities with governance.
• Operationalise strategy via review, training, process management and improvements.
• Use approved AI tools with human oversight to improve quality and cycle time.
• Build understanding of rare disease portfolio, pathways and codes across stakeholders.
• Complete timely, accurate reviews aligning with ABPI/IPHA Codes and internal standards.
• Maintain knowledge of portfolio, services and patient pathways.
• Partner across functions to deliver compliant, patient-centred solutions.
• Provide guidance on novel, high-risk questions and coordinate third-party signatory support.
• Maintain review procedures and identify AI use cases across triage, review, checks, reporting.
• Work with Digital/Ops, Privacy, Legal, Compliance and InfoSec on pilots and adoption.
• Use data and AI patterns to spot training needs and standardisation opportunities.
• Deliver training on SOPs, Codes and responsible AI use.
• Support coaching, validation and revalidation as delegated.

Skills

Medical ethics

ABPI Code knowledge

Stakeholder management

AI-enabled tools

Analytical thinking

Clear communication

Regulatory compliance

Cross-functional collaboration

Governance & signatory

Learning agility

Education

Medical degree or Pharmacist qualification

Tools

AI-enabled tools

Digital/Data tools

Job description

Alexion in London seeks a Medical Ethics Manager to enable patient-centered activities while ensuring compliance with ABPI/IPHA Codes. You will act as a Nominated Signatory, oversee signatory processes, and drive governance, training and continuous improvement across UK & Ireland Rare Disease.

You will use approved AI-enabled tools with robust human oversight to enhance review quality, maintain confidential information, and collaborate with Digital/Ops, Privacy, Legal and Compliance teams.