Protein Scientist

TN United Kingdom; London; On-site; GBP 40,000 - 80,000; Full time

Job summary

An innovative biotech company in London seeks a skilled Protein Biochemist to join their dynamic team. This exciting role focuses on cutting-edge drug discovery, emphasizing protein quality control for antibody immunizations and candidate screening. You will establish in-house protein production capabilities, conduct molecular biology tasks, and support drug validation experiments using state-of-the-art techniques. Join a diverse team dedicated to improving patient outcomes in diseases like fibrosis and cancer, with access to advanced facilities and a competitive benefits package.

Benefits

Private healthcare

Bonus

Pension

State-of-the-art facilities

Diverse team environment

Qualifications

• Experience in biotech or pharma labs with recombinant protein production.
• Strong skills in protein purification and biophysical characterization.

Responsibilities

• Establish in-house protein production and quality control capabilities.
• Conduct assays to assess protein functionality and support drug screening.

Skills

Protein purification

Cell culture

Molecular biology

Biophysical characterization

Assay development

Education

PhD in Biochemistry

MSc in Biochemistry

Tools

AKTA FPLC

SDS-PAGE

HPLC

Western blots

Job description

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Job Title: Protein Biochemist

We are seeking a highly skilled and motivated protein biochemist who is duel-skilled in cell culture to join our dynamic team. This role offers an exciting opportunity to contribute to cutting-edge drug discovery projects, focusing on the quality control of protein reagents for antibody immunisations, candidate screening, and biophysical profiling of drug leads.

Responsibilities:

1. Establish and develop in-house protein production capabilities. Operate and maintain an AKTA FPLC, manage suspension/transient mammalian cell lines, and perform protein quality control.
2. Support drug screening and validation experiments. Conduct assays such as ELISAs and cell-based assays to assess protein functionality, using over-expressing or primary cell lines.
3. Molecular biology: Design DNA constructs and vectors for protein overexpression.
4. Cell biology: Perform tissue culture, cell banking, and monitor cell health and viability. Support cell-based drug screening assays.
5. Protein purification: Design and oversee purification protocols using chromatography techniques.
6. Biophysical analysis and QC: Conduct and interpret SDS-PAGE, Western blots, ELISAs, endotoxin testing, HPLC, BLI, SPR, and analyze protein stability and interactions.

Qualifications:

• Experience working in a laboratory within biotech, pharma, or related environments.
• Proven experience in producing recombinant proteins from mammalian cell lines.
• Skilled in protein purification, biophysical characterization, and QC techniques.
• PhD in Biochemistry or related field with 2-3 years post-qualification experience, or MSc with equivalent experience.
• Strong communication skills and meticulous record-keeping.

Why Join Us?

• Be part of a motivated, diverse team supporting innovative drug discovery.
• State-of-the-art facilities at Westworks, White City.
• Competitive package including private healthcare, bonus, pension, and more.

About Us:

Engitix is a growing biotech company in White City, London, dedicated to developing therapies for fibrosis and tumors using our pioneering ECM platform, enabling advanced 3D in vitro models for drug discovery and biomarker development.

Join us in our mission to improve patient outcomes in diseases like fibrosis and cancer.