Principal Scientist, Small Molecule LC-MS/MS Bioanalysis

Simbec-Orion Group; United Kingdom; Remote; GBP 65,000 - 90,000; Full time

Job summary

Simbec-Orion Group is seeking a Principal Scientist to lead our LC-MS/MS bioanalysis efforts across oncology, rare disease and clinical pharmacology studies. You will own method development and validation on triple quadrupole platforms, troubleshoot challenges, and act as the technical authority from client onboarding to final report.

This hands‑on role requires mentoring the team, setting strategy for LC-MS/MS, and representing Laboratory Services with clients, auditors and Sponsors.

Qualifications

• Extensive hands‑on experience with LC-MS/MS (triple quadrupole) in a regulated laboratory environment (GCP, GLP and/or GMP).
• Proven track record leading method development and validation for small molecule bioanalysis.
• Strong grounding in extraction technique (protein precipitation, LLE, SPE) and chromatographic troubleshooting.
• Working knowledge of current bioanalytical method validation guidance.
• Demonstrable ability to review and approve technical documentation to GxP standard.
• Experience managing study timelines and priorities under deadline pressure.

Responsibilities

• Lead LC-MS/MS method development and validation, from extraction strategy through to fully validated assay.
• Troubleshoot instrument and method issues, acting as technical escalation point for the team.
• Take scientific accountability for assigned studies: data integrity, regulatory compliance, and final reporting.
• Review and approve protocols, validation reports, SOPs and study documentation.
• Mentor scientists developing their LC-MS/MS technique.
• Represent Laboratory Services with clients, auditors and Sponsors, and support Business Development with technical input.

Skills

LC-MS/MS method development

Triple quadrupole bioanalysis

Extraction techniques

GxP regulatory compliance

Study timeline management

Technical documentation review

Education

MSc or PhD in a scientific discipline

Tools

Analytical instrumentation software

Job description

Simbec-Orion Group is seeking a Principal Scientist to lead our LC-MS/MS bioanalysis efforts across oncology, rare disease and clinical pharmacology studies. You will own method development and validation on triple quadrupole platforms, troubleshoot challenges, and act as the technical authority from client onboarding to final report.

This hands‑on role requires mentoring the team, setting strategy for LC-MS/MS, and representing Laboratory Services with clients, auditors and Sponsors.