Lead Small Molecule LC-MS/MS Bioanalysis Scientist

Simbec-Orion

Merthyr Tydfil

On-site

GBP 65,000 - 95,000

Full time

3 days ago

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Job summary

Simbec-Orion is seeking a Principal Scientist to lead our small molecule LC-MS/MS bioanalysis, working across oncology, rare disease and clinical pharmacology studies. You will take ownership of method development and validation on triple quadrupole platforms, troubleshoot complex extraction and chromatographic issues, and act as the technical authority for the studies you run, from client onboarding through to final report.

This is a hands-on technical role with real scientific ownership.

Qualifications

Extensive hands-on LC-MS/MS experience in a regulated lab (GCP/GLP/GMP).
Proven track record leading method development and validation for small molecule bioanalysis.
Strong grounding in extraction techniques (PPI, LLE, SPE) and chromatographic troubleshooting.
Knowledge of current bioanalytical method validation guidance (GxP).
Ability to review/approve technical documentation to GxP standards.
Experience managing study timelines and priorities under deadline pressure.

Responsibilities

Lead LC-MS/MS method development and validation, from extraction strategy through to fully validated assay.
Troubleshoot instrument and method issues, acting as technical escalation point for the team.
Take scientific accountability for assigned studies: data integrity, regulatory compliance, and final reporting.
Review and approve protocols, validation reports, SOPs and study documentation.
Mentor scientists developing their LC-MS/MS technique.
Represent Laboratory Services with clients, auditors and Sponsors, and support Business Development with technical input.