Principal Scientist PK/PD

UCB S.A.; Princes Risborough; Hybrid; GBP 90,000 - 120,000; Full time

Job summary

UCB is seeking a Principal Scientist, Non-Clinical PKPD, to lead the PKPD strategy across projects from discovery to clinic. Based in the UK with hybrid arrangements, you will drive modelling efforts and collaborate with Clinical Development Sciences to translate nonclinical findings into clinical decisions.

You will represent PKPD in internal and external forums, contribute to the scientific reputation of UCB, and partner with Safety, Bioanalysis and Translational Medicine teams to optimize

Qualifications

• PhD in pharmacology, pharmaceutical sciences, PK/PD, systems biology or related field.
• Strong understanding of pharmacology and pharmacologic disease mechanisms.
• Expertise in PKPD methods and modelling; systems modelling advantageous.
• Experience developing non-clinical PKPD strategies from discovery to clinic.
• Experience leading in a matrix environment with stakeholders including Non-Clinical Safety, Bioanalysis, Clinical Pharmacology and Translational Medicine.
• Experience using modelling and simulation packages.

Responsibilities

• Develop and drive the nonclinical PKPD strategy for projects.
• Communicate effectively ensuring implementation in projects.
• Translate in vitro data and in vivo nonclinical studies to prediction of efficacy and safety in patients.
• Initiate collaborations to advance drug candidates and build PKPD knowledge.
• Build PKPD models of sufficient complexity to inform hypothesis testing and decision-making.
• Represent PKPD interests and enhance scientific reputation of Non-Clinical PKPD, QCP and UCB.
• Provide input into regulatory study protocols, reports and submission documents.

Skills

Pharmacology expertise

PKPD methods

Systems modelling

Non-clinical PKPD strategy

Matrix leadership

Modelling & simulation

Education

PhD in pharmacology or related field

Tools

Phoenix

Berkeley Madonna

R

Monolix

Job description

department, is responsible for providing strategy and support in bioanalysis, immunogenicity, safety, pathology, and regulatory activities. Work with external partners, academic institutions, CROs and consultants as required.

What you'll do

• Develop and drive the nonclinical PKPD strategy for projects.
• Communicating effectively ensuring implementation in projects.
• Ensure translation from in vitro data and in vivo nonclinical studies to prediction of efficacy and safety in patients.
• Initiate and engage in multifunctional collaborations to facilitate the advancement of drug candidates and build a thorough knowledge of drug pharmacology and PKPD, leading to quantitative translation to the clinic.
• Build PKPD models of sufficient complexity to allow hypothesis testing and inform decision-making.
• Represent the interests of QCP internally and externally in matters relevant to mechanistic PKPD and contribute to enhancing the scientific reputation of Non-Clinical PKPD, QCP and UCB.
• Provide required support and input into regulatory study protocols, reports and summaries, and regulatory submission documents.

Required skills and experience

• PhD in relevant discipline (pharmacology, pharmaceutical sciences, pharmacokinetics/pharmacodynamics, system biology or related fields).
• Good understanding of pharmacology and pharmacologic processes related to disease and drug mechanisms.
• Expertise and proven application of PKPD methods and concepts in support of drug discovery and development; systems modelling experience would be advantageous.
• Demonstrated experience in developing and executing effective non-clinical PKPD strategies from early discovery through to clinic.
• Demonstrated experience and leadership skills working within a matrix environment with a wide range of internal stakeholders including Non-Clinical Safety, Bioanalysis, Clinical Pharmacology and Translational Medicine.
• Experience in using modelling and simulation packages such

About the role

We are looking for a Principal Scientist, Non-Clinical PKPD, who is innovative and agile to join us in our Clinical Development Sciences Group, based at the R&D site in Slough, UK, then Windlesham, Surrey (#####).

Who you'll work with

We operate and collaborate closely with colleagues in Development Sciences, which, as a, as Phoenix, Berkeley Madonna, R and Monolix.

About us

UCB is a global biopharmaceutical company, focusing on neurology and immunology. We are over 9.000 people in all four corners of the globe, inspired by patients and driven by science.

Why work with us?

At UCB, we don't just complete tasks, we create value. We aren't afraid to push forward, collaborate, and innovate to make our mark for patients. We have a caring, supportive culture where everyone feels included, respected, and has equal opportunities to do their best work. We 'go beyond' to create value for our patients, and always with a human focus, whether that's on our patients, our employees, or our planet.

Working for us

Working for us, you will discover a place where you can grow, and have the freedom to carve your own career path to achieve your full potential. At UCB, we've embraced a hybrid-first approach to work, bringing teams together in local hubs to foster collaborative curiosity. Unless expressly stated in the description or precluded by the nature of the position, roles are hybrid with 40% of your time spent in the office.

UCB is an equal opportunity employer. All employment decisions will be made without regard to any characteristic protected by applicable laws.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on #####. Please note should your enquiry not relate to adjustments; we will not be able to support you through this channel.

Job Summary

Job number: 92379

Date posted :#####6-04-28

Profession: Research & Development

Employment type: Permanent