Principal Scientist, Hepatocyte Biology & Gene Therapy

Singular: Building Brilliant Biotechs; Macclesfield; On-site; GBP 65,000 - 100,000; Full time

Job summary

Singular: Building Brilliant Biotechs is seeking a Principal Scientist with deep expertise in primary hepatocytes and gene delivery to lead key cell biology programmes. This senior, hands-on role offers ownership and visibility within a growing multidisciplinary team.

You will bridge in vitro validation and in vivo development, contribute to proof-of-concept data, and shape project direction in a collaborative biotech environment.

Qualifications

• PhD in Life Sciences or a related discipline.
• 5-10 years of experience in cell biology, gene therapy, or a related field.
• Experience handling hepatocytes or tissue-derived primary cells.
• Understanding of gene editing technologies and their application.
• Nice to have: CRISPR or related gene editing experience in primary tissues.
• Nice to have: Familiarity with CTA or IND-enabling activities.

Responsibilities

• Leading cell biology activities supporting gene therapy programme development.
• Designing and executing experiments using primary hepatocytes and other relevant cell types.
• Supporting outsourced in vivo studies and external research collaborations.
• Generating scientific data packages for internal decision-making and external partners.
• Providing technical leadership while remaining actively involved in laboratory research.

Skills

Cell biology

Gene therapy

Primary cells

Project ownership

Education

PhD in Life Sciences

Tools

CRISPR

Cell culture

Job description

Singular: Building Brilliant Biotechs is seeking a Principal Scientist with deep expertise in primary hepatocytes and gene delivery to lead key cell biology programmes. This senior, hands-on role offers ownership and visibility within a growing multidisciplinary team.

You will bridge in vitro validation and in vivo development, contribute to proof-of-concept data, and shape project direction in a collaborative biotech environment.