Associate Director, Translational Biomarkers and Bioanalysis

Singular: Building Brilliant Biotechs; Oxford; On-site; GBP 90,000 - 140,000; Full time

Job summary

Singular: Building Brilliant Biotechs in Oxford is seeking a Principal Scientist to own the translational bioanalysis and biomarkers portfolio for a lead biologic. You will shape strategy, drive biomarker programs, and ensure readiness for first-in-human studies.

You will lead cross-functional efforts across preclinical and IND-enabling work, collaborating with CROs and internal teams to translate assays into regulated, fit-for-purpose bioanalytical approaches in a fast-paced biotech environment.

Qualifications

• PhD or equivalent in biology, biochemistry, or a related field.
• Proven track record delivering biomarker strategies for biologics.
• Experience translating research assays into regulated, fit-for-purpose bioanalytical assays.
• Strong communicator with ability to influence across teams.

Responsibilities

• Define and lead integrated biomarker strategies across preclinical and IND-enabling studies.
• Translate research assays into regulatory-ready bioanalytical assays in GxP environments.
• Own bioanalytical planning for IND/CTA readiness and Phase 1.
• Manage CROs and bioanalytical vendors, including transfers and oversight.

Skills

Translational bioanalysis

Biomarker development

IND-enabling studies

Communication leadership

CRO/vendor management

Education

PhD in biology/biotech

Job description

Principal Scientist – Translational Bioanalysis & Biomarkers // Biologics // Oxford

You are an experienced translational scientist working at the interface of bioanalysis, biomarkers, and drug development. You’ve taken biologics through preclinical development and towards the clinic, and you understand what it takes to translate assays into a regulated environment.

You want to own a programme-facing role where you define strategy, not just execute it. You want visibility, influence, and the chance to take a novel molecule into first-in-human studies.

We are partnering with an Oxford-based biotech unlocking new therapeutic targets through deep understanding of 3D genome regulation. As they transition into a clinical-stage company, they are building the translational capability to take their lead biologic into Phase 1.

This is a pivotal hire. You will become the internal expert in bioanalysis and biomarkers, owning strategy and delivery for the flagship programme.

THE ROLE

As Principal Scientist – Translational Bioanalysis & Biomarkers, you will lead the design and execution of biomarker and bioanalytical strategies across preclinical and IND-enabling studies, ensuring readiness for clinical development.

You will operate across disciplines, externally with CROs, and internally as the biomarker leader on programme teams.

KEY RESPONSIBILITIES

• Define and implement integrated biomarker strategies (PK, ADA, PD, target engagement, exploratory biomarkers)
• Translate research assays into fit-for-purpose bioanalytical assays in GxP environments
• Own bioanalytical planning for IND/CTA-enabling studies and Phase 1 readiness
• Manage CROs and bioanalytical vendors, including assay development, qualification, transfer, and oversight

ABOUT YOU

• Strong experience in translational bioanalysis and biomarkers within biotech/pharma
• Proven track record supporting biologics through preclinical and IND-enabling stages
• Strong communicator, able to influence without direct authority
• Collaborative, hands‑on, and comfortable operating in a fast‑paced biotech environment

LOGISTICS

• Location: Oxford (on‑site)
• Level: Principal Scientist

If you want to take ownership of a flagship programme and build translational strategy from preclinical through to clinic, apply here.