Principal Scientist - Biologics Process Development Leader

Lonza; Cambourne; On-site; Confidential; Full time

Job summary

Lonza Cambridge is seeking a Principal Scientist to lead development and optimization of biopharmaceutical manufacturing processes. You will guide strategic projects across clinical and commercial phases, oversee experiments, and mentor junior scientists.

You will design studies, analyze data, and produce regulatory documents while collaborating with manufacturing, quality, and regulatory teams to deliver high-quality outcomes.

Qualifications

• PhD with 5+ years in biopharma industry or MS with 10+ years.
• Experience with vector/host cell engineering to integrate payloads or knockout gene function.
• Strong knowledge of upstream and downstream biologics processing.
• DOE, statistics, data interpretation and modern lab instrumentation.

Responsibilities

• Translate market insights into growth strategies across clinical and commercial phases.
• Lead projects on process development, optimization, and characterization of biologics.
• Design experiments, analyze data, and interpret results to improve process understanding and development.
• Author and review technical reports, protocols, and regulatory documents in support of process development and manufacturing.
• Provide scientific leadership and mentorship to junior scientists and research staff.
• Troubleshoot complex technical challenges and develop innovative solutions to improve yield and product quality.
• Collaborate with cross-functional teams (manufacturing, QC, regulatory) for project execution.
• Stay current with industry trends and technologies in biopharmaceutical process development.
• Present findings at internal and external conferences.

Skills

DOE

Statistical analysis

Scientific leadership

Data interpretation

Communication skills

Independent worker

Education

PhD in chemical/biochemical eng

MS with 10+ years experience

Tools

DOE tools

Statistical software

Chromatography

Filtration

Job description

Lonza Cambridge is seeking a Principal Scientist to lead development and optimization of biopharmaceutical manufacturing processes. You will guide strategic projects across clinical and commercial phases, oversee experiments, and mentor junior scientists.

You will design studies, analyze data, and produce regulatory documents while collaborating with manufacturing, quality, and regulatory teams to deliver high-quality outcomes.