Principal Scientist

ZipRecruiter; Cambridge; On-site; GBP 70,000 - 100,000; Full time

Job summary

A leading company is seeking a Principal Scientist in Enzymology to provide scientific leadership and innovate within drug discovery. This role involves developing biochemical assays, characterising cancer targets, and managing team performance. Ideal candidates will have a strong background in enzymology and a PhD or equivalent experience.

Qualifications

• PhD in Enzymology, Pharmacology, or equivalent experience.
• Significant experience and expertise in enzymology in drug discovery.
• Detailed understanding of enzymology, biochemical assays, and detection technologies.

Responsibilities

• Provide scientific leadership to define and implement best practices for biochemical assays.
• Design novel physiologically relevant biochemical assays and characterise cancer targets.
• Manage performance and development of line reports.

Skills

Enzymology

Pharmacology

Biochemical assays

Mechanistic studies

Education

PhD in Enzymology or equivalent

Job description

Job Description

Principal Scientist – Enzymology

Cambridge

Permanent

SRG are currently supporting the search for a Principal Scientist with an expertise in enzymology.

You will be an inspirational scientist with an exceptional record of bringing your deep knowledge of enzymology and biochemistry to impact on projects. Within this role you will be brining scientific leadership to the design of biochemical assays and bespoke mechanistic data helping to characterise cancer targets.

The Role:

• Provide scientific leadership to define and implement best practice for biochemical assays and bespoke mechanism of action studies.
• Design and develop novel physiologically relevant biochemical assays for a range of target classes, using recombinant proteins
• Characterise cancer targets in detail at the molecular level
• Define biochemical profiling cascade to support characterisation of novel small molecules for oncology targets
• Characterise small molecules in vitro using recombinant proteins and a range of biochemical assay technologies, with a particular focus on detailed kinetic and mechanism of inhibition studies and their translation into the cellular environment.
• Represent the department across a broad range of projects and cross-site initiatives, both internally and externally.
• Prioritise own work and that of line reports according to project goals and take responsibility for the timely delivery of team objectives
• Manage performance and development of line reports

Requirements:

• PhD (or equivalent) in Enzymology, Pharmacology, or equivalent experience
• Significant experience and deep expertise in enzymology in a drug discovery environment
• Detailed understanding of steady-state and pre-steady-state enzymology. Experience in Modelling and Simulation will be an advantage.
• Detailed theoretical and practical understanding of biochemical assays and detection technologies, with a particular focus on physiologically relevant systems
• Significant experience of assay development for a range of target classes
• Strong external reputation in enzymology, evidenced through wide personal network, external presentation and publication, and presentation at key conferences.

Apply now by attaching your CV in Word, or contact Selby De Klerk for further information about this new role: [e-mail]