Principal Scientist Quantitative Systems

ZipRecruiter; Cambridge; On-site; GBP 50,000 - 90,000; Full time

Job summary

A leading global healthcare company is looking for a Principal Scientist in Quantitative Systems to aid drug discovery through innovative modeling. The role requires a PhD and experience in disease modeling, providing an opportunity to contribute significantly to R&D efforts while enjoying a comprehensive rewards package and career growth prospects.

Benefits

Opportunities for growth and career development

Comprehensive rewards package

Health and wellbeing benefits

At least 14 weeks of parental leave

Qualifications

• PhD with a strong publication record in relevant fields.
• At least 2 years of postdoctoral experience in disease modeling.
• Experience in drug discovery/development is a plus.

Responsibilities

• Develop and apply multiscale computational models of complex diseases.
• Analyze simulation results and improve model performance.
• Communicate modeling predictions to key stakeholders.

Skills

Mathematical modeling using differential equations

Excellent communication skills

Collaboration in teams

Detail-oriented

Independent research

Education

PhD in systems pharmacology/biology, computational biology, biomedical engineering, or related fields

Tools

MATLAB

Julia

R

Job description

Job Description

Job Title: Principal Scientist Quantitative Systems

Location: Waltham, MA

About the Job

Are you ready to shape the future of medicine? The company is on a mission to accelerate drug discovery and development to find answers for patients and their families. Your skills could be critical in helping teams accelerate progress. Join our Quantitative Systems Pharmacology (QSP) group as a Principal Scientist to support our R&D portfolio with mechanistic disease modeling.

This position is based in Cambridge, MA.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities:

• Function as part of a team to develop and apply multiscale computational models of complex diseases based on detailed biological mechanistic knowledge to support model-informed drug discovery & development.
• Survey literature to understand critical physiological processes, identify suitable mechanistic elements, data, parameters, and assumptions to include.
• Identify and analyze suitable internal preclinical and clinical data to inform modeling activities.
• Analyze simulation results and identify strategies to improve model performance and accuracy.
• Maintain extensive documentation of model development and data analysis processes.
• Maintain expertise in quantitative systems pharmacology through ongoing education.
• Communicate modeling predictions to key stakeholders effectively.

About You:

• PhD with a strong publication record in systems pharmacology/biology, computational biology, biomedical engineering, or related fields.
• At least 2 years of postdoctoral experience in disease modeling/QSP.
• Experience in drug discovery/development, bioinformatics, or pharmacometrics is a plus.
• Proficiency in mathematical modeling using differential equations.
• Extensive experience with computational tools such as MATLAB, Julia, and R.
• Excellent communication skills, both oral and written.
• Ability to quickly learn pathophysiology and treatment approaches in immunology.
• Highly motivated, detail-oriented, and independent researcher.
• Ability to thrive in a collaborative, multidisciplinary team environment.
• Strong commitment to on-the-job training.

Why Choose Us?

• Join a supportive, future-focused team dedicated to bringing the miracles of science to life.
• Opportunities for growth and career development, both locally and internationally.
• Comprehensive rewards package recognizing your contributions.
• Health and wellbeing benefits, including high-quality healthcare, wellness programs, and at least 14 weeks of parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a diverse workforce. All qualified applicants will receive consideration regardless of various protected characteristics.