Principal Bioinformatician / Computational Biologist, Drug Safety

Tagomics Ltd.; Cambridge; Hybrid; GBP 90,000 - 130,000; Full time

Benefits offered by this job

Competitive salary

Share option scheme

Matched pension contributions

Private healthcare

Performance-related bonus

Flexible hybrid working (minimum 2 on‑

Job summary

Tagomics Ltd. in Cambridge is seeking a hands-on Principal Scientist in bioinformatics to develop computational methods for epigenetic markers from cell-free DNA and lead two senior bioinformaticians. You will work directly with data, partners, and the programme while shaping technical strategy.

The role focuses on delivering science, software, and analyses for drug safety, with opportunities to contribute to publications and IP within a fast-growing biotech setting.

Qualifications

• PhD in bioinformatics, computational biology, or related field.
• 8+ years research/industry experience.
• Hands-on coding in Python and/or R.
• Experience with omics data analysis.
• Ability to lead and develop others.
• Experience working with external partners in a commercial setting.

Responsibilities

• Develop, build and evaluate novel computational methods for epigenetic markers from cell-free DNA.
• Adapt or write bioinformatics software with our engineering team.
• Drive toxicity biomarker discovery and refinement.
• Translate findings into outputs partners can act on.
• Lead computational strategy and priority setting.
• Collaborate on experimental designs and controls.
• Present results to partner scientists and decision-makers.
• Lead and develop two senior bioinformaticians.
• Contribute to publications and IP.

Skills

Python

R

Bioinformatics

Omics

Statistics

Education

PhD in bioinformatics

Tools

MeDIP-seq

ATAC-seq

ChIP-seq

WGBS

RNA-seq

Git

Job description

Read Our Recent Scientific Paper

https://www.cell.com/cell-reports-methods/fulltext/S2667-2375(25)00223-1

Help build the future of drug safety monitoring

Drug-induced toxicity remains one of the biggest causes of drug-development delay, clinical failure and patient harm. Current monitoring is often insensitive, organ-specific and reliant on damage becoming clinically apparent. We think there is a better way.

Tagomics is a Cambridge-based biotechnology company developing a next-generation multi-omic biomarker platform. Originating from pioneering research by Dr Robert Neely and colleagues at the University of Birmingham, our proprietary technology captures epigenetic features from circulating cell-free DNA that, when combined with advanced bioinformatics, let us detect and localise tissue injury across multiple organs, giving drug developers earlier and more biologically precise insight into treatment-related toxicity.

With successful proof-of-concept programmes behind us and pharmaceutical partners already engaged, we are building towards our first commercial products at Babraham Research Campus.

Read Our Recent Scientific Paper

https://www.cell.com/cell-reports-methods/fulltext/S2667-2375(25)00223-1

The role

This is a hands-on principal scientist role, not a management-only role. You will spend most of your time (around 70%) doing the science yourself: developing methods, writing code and working directly with the data. The rest of your time will be working with partners, team leadership and technical strategy.

You will be the most technically experienced bioinformatician on the drug safety programme. You will line-manage two senior bioinformaticians who are already strong practitioners, so we need someone with the depth to review their methods, support their technical development, and be someone they can bring difficult problems to.

You will also be key to our work with pharmaceutical partners. That means helping to design studies with them, explaining what the data can and can't tell them, and presenting results in a way that supports their decisions.

What You'll Be Doing

Do the science

• Develop, build and evaluate novel computational methods for epigenetic markers from cell-free DNA
• Adapt or write bioinformatics software alongside our software engineering team where existing tools fall short
• Drive toxicity biomarker discovery and refinement
• Translate findings into outputs partners can act on

Set the analytical direction

• Lead computational strategy independently, translating programme objectives into bioinformatics/analytical priorities
• Shape experimental designs (considering power/sample size, batch effects etc.), and plan appropriate controls
• Collaborate on long-term assay and product development

Work with partners

• Contribute to technical discussions with pharmaceutical and biotech partners, from study scoping through to results
• Present findings to partner scientists and decision-makers alongside our Programme Lead
• Help turn partner questions into well-designed studies and analyses

Lead and develop the team

• Lead, coach and technically challenge two senior bioinformaticians
• Set standards for methods, code quality and reproducibility across the programme
• Contribute to publications, IP and conference presentations

Essential

What we're looking for

• PhD in bioinformatics, computational biology, or related fields, followed by substantial experience (8+ years) in industry or academia
• Current, hands‑on coding expertise in Python and/or R. You should still be writing substantial analytical code in your current role
• In-depth knowledge of at least one omics technology
• A track record of developing new computational methods
• Experience applying statistical modelling or machine‑learning methods to complex biological datasets
• Proven ability to set computational strategy and manage projects independently
• Experience developing the technical skills of other bioinformaticians
• Experience working with external partners, customers or collaborators in a commercial setting

Nice‑to‑have

• Python as your main language
• Knowledge of liquid biopsy, clinical studies or the drug development life cycle
• Previous line management experience
• Experience analysing epigenetic and/or transcriptomic datasets (e.g. MeDIP-seq, ATAC-seq, ChIP-seq, WGBS, RNA-seq)
• Knowledge of software engineering best practices: testing, code review, version control
• Experience in multi-disciplinary teams, including with laboratory members
• Startup, biotech or pharma experience

Who You Are

• You love solving problems and getting your hands dirty fixing them, alongside your team
• You can explain a complex result at the right level for your audience, from a five‑minute summary for a commercial partner to a deep technical discussion with a bioinformatician
• You want to work on a brand‑new technology that can change how drug toxicity is detected and monitored, with all the challenges that brings

Our hiring process

• Online screening call: your experience, goals and questions about the role
• Online technical interview: technical questions and a presentation of a take-home bioinformatics challenge, where we expect this would take up to 3 hours to prepare.
• In‑person team interview: meet leadership and your future colleagues

What We Offer

• Competitive salary
• Share option scheme
• Matched pension contributions up to 8%
• Private healthcare with Aviva
• Performance‑related bonus scheme
• Flexible hybrid working (minimum 2 days per week on‑site)
• 25 days holiday plus bank holidays, and a discretionary 3-day Christmas shutdown

We're based at Babraham Research Campus, one of Europe's leading life‑science hubs, with modern accessible offices, on‑site parking, a gym, restaurant and countryside on the doorstep.

We are not currently able to sponsor visas for this role. Applicants must have the right to work in the UK. No agencies please.

Tagomics is committed to building a diverse and inclusive team.