Principal Analytical Scientist

ENTRUST PEOPLE LIMITED; England; On-site; CAD 94,000 - 115,000; Full time

Job summary

ENTRUST PEOPLE LIMITED in SE England is seeking a Principal Analytical Chemist to lead complex GMP‑driven method development and validation using LC‑MS/HPLC on API and synthesized chemicals. This hands‑on role combines technical excellence with team leadership in a busy manufacturing environment.

You will mentor staff, troubleshoot instruments, collaborate with process chemists, and deliver robust analytical projects while ensuring GMP compliance and high‑quality documentation.

Qualifications

• Candidates hold a BSc/MSc/PhD in Analytical Chemistry with hands-on GMP method development and validation experience using chromatography in API/synthesis environments.

Responsibilities

• Lead a small team of Analytical Chemists and guide project work.
• Troubleshoot instruments and methods to enable timely analyses.
• Collaborate with Synthetic/Process Chemists to understand synthesized chemicals for robust analyses.
• Lead analytical projects, define scope and milestones with GMP compliance.
• Perform analyses with various chromatography, spectroscopy techniques including NMR and ICP.
• Complete GMP documentation and reports to ensure analytical success.
• Explore new analytical methodologies and implement method improvements.
• Train and mentor colleagues, leading by example on complex problem solving.

Skills

Team leadership

Problem solving

GMP knowledge

Mentoring

Education

BSc in Analytical Chemistry

MSc in Analytical Chemistry

PhD in Analytical Chemistry

Tools

LC-MS/HPLC

NMR

ICP

Job description

Principal Analytical Chemist
SE England
Permanent

09th November, 2026

Our SE based client is currently looking to recruit a Principal Analytical Chemistto perform complex method development and validation using LC-MS/ HPLC on a variety of synthesised chemicals and API molecules. This is a hands‑on role and would suit someone who enjoys developing novel methods from first principles in busy commercial manufacturing environment.

Additional duties for this role will include :

• Leading a small team of Analytical Chemists, assisting with ongoing project work when required
• Instrument and method trouble‑shooting , solving problems to enable analyses to be completed
• Working with Synthetic / Process Chemists to understand synthesised chemicals to ultimately ensure the successful analysis of a range of molecules
• Leading on a number of analytical projects, understanding GMP requirements and defining scope of analytical projects and milestones
• Understanding / performing analyses with a range of other chromatography, spectroscopy and techniques (including NMR, ICP and others)
• Completing detailed GMP documentation and reports, ensuring analytical success
• Understanding new approaches in analytical methodologies and techniques and implementing method improvements
• Training and mentoring others, leading by example on complex problem solving challenges

Applications are invited from candidates with a BSc, MSc, PhD in Analytical Chemistry (or similar) together with proven demonstrable hands‑on skills performing complex GMP method development and validation using chromatography systems in an API / synthesis environment

Salary : Circa £55,000 (depending on skills and experience)

Role : Permanent

Location : SE England