Principal Analytical Scientist

Entrust Resource Solutions; England; On-site; GBP 50,000 - 61,000; Full time

Job summary

Entrust Resource Solutions is recruiting a Principal Analytical Chemist for a permanent role in SE England. The role involves hands-on GMP method development and validation using LC‑MS and HPLC on API/synthetic molecules.

You will lead a small team of analytical chemists and collaborate with process chemists to ensure robust analyses. The ideal candidate holds a BSc/MSc/PhD in Analytical Chemistry with proven hands-on GMP experience, and a track record in troubleshooting and delivering compliant

Qualifications

• Hands-on GMP method development and validation using chromatography systems.
• Experience in API/synthesis environments is advantageous.
• Strong documentation and compliance with GMP.
• Experience leading analytical projects and mentoring staff.

Responsibilities

• Lead a small team of Analytical Chemists and oversee project work.
• Troubleshoot instruments and methods to enable analyses.
• Collaborate with Synthetic/Process Chemists to analyze molecules.
• Define scope, milestones and ensure GMP compliance on projects.
• Perform analyses with chromatography, spectroscopy and related techniques (NMR, ICP).
• Prepare detailed GMP reports and documentation.
• Mentor colleagues and drive method improvements.

Skills

Analytical chemistry

Team leadership

GMP/compliance

Method development

LC–MS / HPLC proficiency

Troubleshooting

Education

BSc/MSc/PhD in Analytical Chemistry

Tools

LC‑MS

HPLC

NMR

ICP

Job description

Principal Analytical Chemist

SE England. Permanent.

Our SE based client is currently looking to recruit a Principal Analytical Chemist to perform complex method development and validation using LC-MS / HPLC on a variety of synthesised chemicals and API molecules. This is a hands‑on role and would suit someone who enjoys developing novel methods from first principles in busy commercial manufacturing environment.

Key responsibilities

• Leading a small team of Analytical Chemists, assisting with ongoing project work when required
• Instrument and method trouble‑shooting , solving problems to enable analyses to be completed
• Working with Synthetic / Process Chemists to understand synthesised chemicals to ultimately ensure the successful analysis of a range of molecules
• Leading on a number of analytical projects, understanding GMP requirements and defining scope of analytical projects and milestones
• Understanding / performing analyses with a range of other chromatography, spectroscopy and techniques (including NMR, ICP and others)
• Completing detailed GMP documentation and reports, ensuring analytical success
• Understanding new approaches in analytical methodologies and techniques and implementing method improvements
• Training and mentoring others, leading by example on complex problem solving challenges

Qualifications and experience

• Must hold a BSc, MSc, PhD in Analytical Chemistry (or similar)
• Proven demonstrable hands‑on skills performing complex GMP method development and validation using chromatography systems in an API / synthesis environment

Salary, contract and location

• Salary: Circa £55,000 (depending on skills and experience)
• Contract type: Permanent
• Location: SE England