Postdoctoral Research Associate - Membrane Protein Folding

1000scholars; Birmingham; On-site; GBP 41,000 - 47,000; Full time

Job summary

Aston University in Birmingham, United Kingdom, invites applications for a Postdoctoral Research Associate to explore fundamental principles of mammalian membrane protein folding and assembly during biogenesis using dynamic mass photometry (DMP). The role sits within the Aston Institute for Membrane Excellence (AIME) and emphasizes interdisciplinary collaboration and rapid technique acquisition.

The successful candidate will combine cell‑free approaches to monitor protein synthesis on ribosomes

Responsibilities

• Conduct research on mammalian membrane protein folding and assembly, using dynamic mass photometry (DMP) to track insertion, folding and assembly in artificial lipid bilayers.
• Apply cell-free methodologies to study translation on ribosomes and protein biogenesis.
• Collaborate within the Aston Institute for Membrane Excellence (AIME) and across disciplines; rapidly learn and apply new techniques.
• Lead independent day-to-day research activities with strong problem‑solving and data analysis skills.

Job description

Postdoctoral Research Associate - Membrane Protein Folding

Aston University

Birmingham, United Kingdom

GBP 41,064 to 46,970 per year

We are seeking a highly motivated Postdoctoral Research Associate to join a newly funded BBSRC Pioneer Award exploring the fundamental principles that govern mammalian membrane protein folding and assembly during biogenesis using dynamic mass photometry (DMP), a label‑free single particle tracking technique.

This position is embedded within the vibrant, collaborative environment of the Aston Institute for Membrane Excellence (AIME). AIME is a first‑of‑its‑kind institute that synergistically combines world‑leading expertise in membrane biology and novel polymer chemistries.

In this highly collaborative project, the successful candidate will combine cell‑free methodologies to track mammalian membrane protein synthesis on ribosomes, using DMP to visualise membrane protein insertion, folding, and assembly within artificial lipid bilayers which mimic mammalian lipid composition.

We are looking for candidates with a strong background in membrane biology protein and lipid biochemistry, or microscopy and image analysis, and a passion for applying multidisciplinary methods to understand de novo membrane protein folding. The ability to rapidly learn new techniques is highly desirable, and enthusiasm for working across disciplinary boundaries is essential. Full training will be provided where needed. Prior experience in independently driving research projects on a day‑to‑day basis is required.