Postdoctoral Research Associate in Proteomics (Microbial Competition and Type VI Secretion)

The University of Manchester; Manchester; In loco; GBP 36.000 - 52.000; Tempo pieno

Vantaggi offerti da questo lavoro

Generous employer contribution pension

29 days annual leave plus bank holiday

Ride to work and EV car scheme

Descrizione del lavoro

The University of Manchester invites applications for a Postdoctoral Research Associate to lead mass spectrometry-based proteomics within a Wellcome Discovery Award on microbial interactions. Work with colleagues from Dundee, Newcastle, Edinburgh and Chicago, using DIA proteomics to characterise T6SS-secreted proteins and define their modes of action.

Based in the Laboratory for Biomedical Mass Spectrometry under Prof Matthias Trost, you will have hands-on access to timsTOF HT and timsTOF Ultra

Competenze

• Hands-on experience running and maintaining mass spectrometry systems.
• Experience in data analysis with R and related bioinformatics.
• PhD (or near completion) in proteomics, microbiology or related field.

Mansioni

• Design and run DIA proteomics experiments on complex microbial samples.
• Run and maintain MS and LC systems.
• Apply data analysis pipelines in R and other bioinformatic analyses.
• Plan experiments with PI and award team; publish findings as lead or co‑author.

Conoscenze

Mass spectrometry

Proteomics

R data analysis

Formazione

PhD (or near completion) in a relevant field

Strumenti

timsTOF HT

timsTOF Ultra

LC-MS systems

Descrizione del lavoro

We are seeking a motivated and collaborative individual to join our team as a Postdoctoral Research Associate in mass spectrometry-based proteomics. You will lead the proteomics work of a collaborative Wellcome Discovery Award on competitive interactions between microorganisms, working with colleagues at the Universities of Dundee, Newcastle, Edinburgh and Chicago. You will use data-independent acquisition (DIA) proteomics to characterise T6SS-secreted proteins and define their modes of action.

You will be based in the Laboratory for Biomedical Mass Spectrometry under the supervision of Prof Matthias Trost, with hands‑on access to modern instrumentation including the timsTOF HT and timsTOF Ultra AIP.

You will be responsible for:

• design and run DIA proteomics experiments on complex microbial samples within the collaborative consortium;
• run and maintain one of the mass spectrometry and LC systems;
• apply data analysis pipelines in R and other bioinformatic analyses;
• plan your own experiments with the Principal Investigator and the wider award team, and publish your findings as lead or co-author.

We welcome candidates who bring diverse perspectives, experiences, and approaches to their work.

About You

We encourage applications from individuals with a wide range of backgrounds and experiences. You should demonstrate:

Essential Criteria:

• You will have a PhD (or be about to obtain one) and proven hands‑on experience running and maintaining mass spectrometry systems, experience in proteomics, and good data analysis skills in R.
• You will collaborate closely with colleagues and also drive your own research questions.

Desirable Criteria:

• Microbiology experience, particularly in bacterial or fungal biology, is an advantage but not essential.

We value transferable skills and real‑world experience as much as formal qualifications.

Our benefits include:

• Generous employer contribution pension
• 29 days annual leave plus bank holidays, along with Christmas closure
• Ride to work and EV car scheme available

For more information, please see here . You can also find information on our Flexible and Hybrid working here .

We are an open place of enquiry and challenge. We embrace and celebrate difference, diversity and debate, and we pride ourselves on being a place of education, learning and community where we are able, within the law, to question and test received wisdom, express new ideas and explore controversial or unpopular topics and opinions. Find out more from our Freedom of Speech here .

Enquiries about the role, shortlisting and interviews

Name: Prof Matthias Trost
Email Address: [e-mail]

General enquiries and administrative support

[e-mail]

Technical and job portal support

Jobtrain Jobseeker Support Hub

Applications close at midnight on the closing date.

Further particulars (with person specification) linked below.