Postdoctoral Research Associate in Nucleic Acid Computing and Molecular Engineering (Fixed Term)

University of Cambridge; Cambridge; Remote; GBP 34,000 - 42,000; Full time

Job summary

The University of Cambridge invites applications for a 2-year Postdoctoral Research Associate position in Nucleic Acid Computing and Molecular Programming under Dr Gamze Gursoy. This bench-based role combines biochemistry, molecular biology and computational genomics to advance privacy-preserving molecular technologies.

The successful candidate will design, build and iteratively improve nucleic-acid systems, analyze experimental data, and collaborate across genetics, computational biology and

Qualifications

• Demonstrated experience designing and experimentally testing nucleic-acid systems beyond routine or kit-based methods.
• Ability to reason about nucleic-acid sequence, structure, recognition, and function to inform experimental design.

Responsibilities

• Design, build and validate nucleic-acid systems for programmable outputs.
• Analyse assay performance and guide iterative design improvements.
• Collaborate across biochemistry, genetics, computational biology and applied mathematics.

Skills

Experimental design

Molecular biology

Data analysis

Nucleic-acid systems

Education

PhD in biochemistry or related field

Tools

Python

R

Job description

# Postdoctoral Research Associate in Nucleic Acid Computing and Molecular Engineering (Fixed Term)We invite applications for a 2-year Postdoctoral Research Associate position in Nucleic Acid Computing and Molecular Programming in the laboratory of Dr Gamze Gursoy at the University of Cambridge.The successful candidate will join an interdisciplinary research programme at the interface of biochemistry, molecular biology, biomolecular engineering, and computational genomics. The current focus is developing new technologies for genetic privacy, a problem requiring molecular and computational systems to be designed together rather than sequentially.The postholder will join an active team developing programmable nucleic-acid systems that sense defined human genomic sequences and convert those molecular recognition events into engineered DNA outputs. The broader aim is to develop molecular systems in which useful genetic information can be measured while limiting direct exposure of the underlying genomic sequence. The successful candidate will help design, build, validate, and iteratively improve these systems, and extend them toward robust, multiplexed privacy-preserving applications.This is primarily an experimental, bench-based position. We are looking for a researcher who enjoys designing and building molecular systems rather than applying established protocols. The postholder will also engage directly with quantitative data generated by their experiments: analysing assay performance, identifying failure modes, comparing alternative designs, and using those results to determine the next experimental iteration. Extensive computational genomics experience is not required, but the ability and willingness to work quantitatively with one's own experimental data is important.The appointee will be expected to plan and manage their own research and administration, with guidance from the PI as required. They will take an active role in the research group, contribute to graduate student research skills, and participate in seminars, workshops, and interdisciplinary collaborations across applied mathematics, genetics, computational biology, synthetic biology, and genomic privacy. They will also be encouraged to develop independent research directions and pursue fellowship funding, with mentorship and support from the PI.Applicants should possess, or be close to completing, a Ph.D. in biochemistry, molecular biology, chemical biology, bioengineering, synthetic biology, biotechnology, or a closely related experimental field.The essential qualification is demonstrated experience designing and experimentally testing nucleic-acid systems beyond routine or predominantly kit-based molecular biology. We are particularly interested in candidates who have reasoned explicitly about nucleic-acid sequence, structure, molecular recognition, enzymatic activity, and function, and translated those ideas into new experimental systems.Refer to the Further Particulars (pg 4) for the full essential/desirable criteria. Experience in all of these areas is not expected. We are more interested in evidence of creative, design-driven molecular thinking and strong experimental problem-solving than in any particular technology.Familiarity with Python, R, or another quantitative analysis environment would be advantageous but is not essential. Candidates with strong experimental backgrounds who are motivated to develop these skills are encouraged to apply.The successful candidate will join an interdisciplinary research environment spanning molecular biology, genomics, cryptography, computational biology, and applied mathematics, with access to wet-lab facilities in the Department of Genetics and close interaction with computational researchers in DAMTP. The project is suited to someone who wants to develop new molecular technologies from first principles, move rapidly between design, experiment, and quantitative analysis, and help establish an emerging area at the boundary of molecular engineering and information security.Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.Please provide the contact details (including email addresses) of two academic referees on the online application form and upload a full curriculum vitae and a description of your recent research (not to exceed three pages). Please ensure that at least one of your referees is contactable at any time during the selection process and is aware that they will be contacted by the Mathematics HR Administrator to upload a reference to our Web Recruitment System. Please encourage them to do so promptly.Informal enquiries can be made by contacting Dr Gamze Gursoy at [e-mail] you have any queries about the application process, please email [e-mail] will be held shortly after the closing date.Please quote reference LE51105 on your application and in any correspondence about this vacancy.The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.The University has a responsibility to ensure that all employees are eligible to live and work in the UK.Apply online