Research Associate (Crossley Group) (Fixed Term)

University of Cambridge; Cambridge; On-site; GBP 42,000 - 54,000; Full time

Job summary

The Crossley Lab at the world-leading CRUK Cambridge Institute invites applications for a Postdoctoral Researcher to investigate RNA-DNA hybrids and their roles in human disease and cancer diagnosis. You will join a collaborative, well-funded team on the Cambridge Biomedical Campus, working at the interface of genome biology, immunity and translational medicine.

Applicants should hold a PhD in a relevant field and demonstrate enthusiasm for experimental, computational or hybrid approaches, with

Qualifications

• PhD in a relevant discipline (awarded or submitted prior to appointment).
• Strong interest in cancer biology, genome biology, RNA biology, immunology or computational biology.
• Excellent scientific, communication and collaborative skills.

Responsibilities

• Conduct research on the mechanisms of RNA-DNA hybrids in cancer and human disease.
• Apply and develop genomic, computational and proteomic approaches as needed.
• Collaborate within the Crossley Lab and with Cambridge institutions to advance projects.

Skills

Scientific excellence

Communication skills

Collaboration

Education

PhD in a relevant discipline

Job description

The Crossley Lab at the world-leading CRUK Cambridge Institute is recruiting an enthusiastic and collaborative Postdoctoral Researcher to help uncover the mechanisms by which RNA-DNA hybrids contribute to human disease and how these pathways can be exploited for cancer diagnosis and treatment.This is an exciting opportunity to join the group at a formative stage, supported by long-term funding from Cancer Research UK and the Wellcome Trust, and to shape a research programme aligned with your expertise and interests.Research OpportunitiesProjects within the lab span:Genome biology of pathological R-loops and their impact on genome stability in cancer and neurodegeneration.Cytoplasmic RNA-DNA hybrids and their role in innate immune signalling.Extracellular RNA-DNA hybrid release and communication between cells.Genomics and computational approaches to study RNA-DNA hybrids in cellular and patient-derived samples.Why Join Us?Exciting science at the intersection of genome stability, immunity and cancer biology.Opportunities to develop and apply cutting-edge approaches including long-read sequencing, proteomics, quantitative imaging and functional genomics.Strong support for publications, fellowship applications and career development.Access to world-class facilities, high-performance computing and specialist training.A highly collaborative research environment on the Cambridge Biomedical Campus, alongside Addenbrooke's Hospital, the MRC Laboratory of Molecular Biology, EMBL-EBI and the Wellcome Sanger Institute.About You You will have:A PhD in a relevant discipline (awarded or submitted prior to appointment).A strong interest in cancer biology, genome biology, RNA biology, immunology, computational biology or a related field.Excellent scientific, communication and collaborative skills.Whether your background is experimental, computational, or a combination of both, we welcome applications from researchers who are excited to contribute to a rapidly emerging area of biology with significant translational potential.Find out more about the Crossley Lab: https://www.cruk.cam.ac.uk/research-groups/crossley-group/Join us and help advance discoveries that could transform our understanding of cancer and other human diseases.Fixed-term: The funds for this post are available for 2 years in the first instance.Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.Please quote reference SW51133 on your application and in any correspondence about this vacancy.The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.The University has a responsibility to ensure that all employees are eligible to live and work in the UK.Apply online