Postdoctoral Research Associate, Cardiocvascular Research

City St George's, University of London; Greater London; Vor Ort; GBP 32.000 - 42.000; Vollzeit

Zusammenfassung

City St George's, University of London invites applications for a postdoctoral researcher to design CRISPR-mediated knockdown of zebrafish orthologues and assess heart function in Brugada-disease models. You will implement new techniques, optimize protocols, and contribute to data analysis with limited supervision in a multi-disciplinary team.

The successful candidate will hold a PhD in molecular biology or related field and have extensive zebrafish husbandry experience, plus skills in

Qualifikationen

• PhD in biology or a closely related field is required.
• Extensive experience with gene editing and functional assays.
• Hands-on expertise in zebrafish husbandry and disease-model development.

Aufgaben

• Design CRISPR-mediated knockdown of zebrafish orthologues.
• Implement and optimize experimental techniques for cardiovascular models.
• Troubleshoot experiments, participate in data analysis and interpretation.

Kenntnisse

PhD in biology

Zebrafish care

Gene editing

Functional assays

Data analysis

Ausbildung

PhD in biology

Tools

CRISPR

Zebrafish techniques

Jobbeschreibung

The main responsibilities of this role will be to design CRISPR-mediated gene knockdown of zebrafish orthologues for novel putative Brugada genes and undertake functional analyses to assess the effect of these knockdowns on heart function. You will also be expected to implement new techniques and optimize protocols critical to the project and provide technical expertise and input for troubleshooting of experiments. It is expected that you will work with limited supervision and contribute to data analysis and interpretation.

We are looking for a person with a PhD in molecular biology, cellular biology, biochemistry or a related discipline. You should have practical expertise with gene editing methodologies and extensive direct experience of zebrafish husbandry techniques and the development of zebrafish disease models. You should also have experience in designing and executing functional assays for evaluating the effects of gene mutations, as well as excellent technical and problem-solving skills, and the ability to work effectively in a multi-disciplinary team.

City St George's, University of London is the University of business, practice and the professions and brings together the expertise and excellence of City, University of London and St George's, University of London into one institution. The combined university is now one of the largest higher education destinations for London students, combining a breadth of disciplines across health, business, policy, law, creativity, communications, science and technology. Our students are at the heart of everything that we do, and we are committed to supporting them to pursue their career and personal ambitions. Our research is engaged, at the frontier of practice and has a positive impact on the world around us.

Background

We are seeking a postdoctoral researcher to join the Cardiovascular Research Institute at City St. George's, University of London, a world-leading centre for investigating the causes of sudden cardiac death in the young. This 18-month post is funded by a Springboard grant from the Academy of Medical Sciences and British Heart Foundation. The project aims to characterise and validate novel genes for Brugada syndrome using zebrafish models, which have recently emerged as an important experimental platform for this arrhythmia disease.