Postdoctoral Fellow: Zinc-Driven Insulin Regulation

University of St Andrews; St Andrews; Hybrid; GBP 36,000 - 45,000; Full time

Benefits offered by this job

Relocation assistance

USS Pension Scheme

Hybrid working

Staff discount scheme

Free staff parking

Carshare and Cycle to Work schemes

Subsidised sports membership

Tuition fee reductions

LinkedIn Learning access

Job summary

University of St Andrews invites applications for a Postdoctoral Research Fellow to study zinc-dependent regulation of insulin multimerisation in pancreatic beta-cells. The role involves advanced fluorescence imaging, FRET, FLIM, and biophysical techniques to understand insulin behaviour in physiologically relevant systems.

The successful candidate will collaborate with colleagues at St Andrews and Dundee, contribute to data analysis, publications and conferences, and may supervise student

Qualifications

• PhD in a related field; near completion acceptable.
• Expertise in advanced fluorescence microscopy, single-molecule detection, live-cell imaging or related areas.
• Experience with quantitative biological sciences and cell signalling is advantageous.

Responsibilities

• Investigate how zinc, pH, serum albumin and free fatty acids regulate insulin multimerisation, storage, release and signalling.
• Develop and apply fluorescence and imaging approaches including FRET, FLIM and live-cell microscopy.
• Contribute to data analysis, publication of results, conference presentations and supervision of students where appropriate.

Skills

Fluorescence microscopy

Live-cell imaging

Single-molecule detection

Protein biophysics

Cell signalling

Quantitative biology

Education

PhD in cell biology/biochemistry/biophysics/molecular biology/biomedical sciences or related

Tools

Genetic code expansion

Click chemistry

FRET-based assays

Fluorescence lifetime imaging (FLIM)

Job description

University of St Andrews invites applications for a Postdoctoral Research Fellow to study zinc-dependent regulation of insulin multimerisation in pancreatic beta-cells. The role involves advanced fluorescence imaging, FRET, FLIM, and biophysical techniques to understand insulin behaviour in physiologically relevant systems.

The successful candidate will collaborate with colleagues at St Andrews and Dundee, contribute to data analysis, publications and conferences, and may supervise student