Structural Biology Associate: Bacterial Secretion Systems

Imperial Enterprise; Greater London; On-site; GBP 45,000 - 49,000; Full time

Job summary

Imperial College London seeks a structural biologist to lead a project on bacterial secretion systems, including Tad and Type 4 pilus systems. You will progress from cloning through purification to structure determination using cryo-EM and related methods.

Applicants should have a PhD in structural biology with a strong publication record; experience in membrane proteins and advanced microscopy is desirable. This is a full-time, fixed-term role funded by an 8-year Wellcome Trust Discovery award.

Qualifications

• PhD in structural biology or equivalent required.
• Experience with protein purification and structure determination workflows.
• Strong background in cryo-EM or X-ray crystallography or NMR.
• Experience with membrane protein complexes is desirable.

Responsibilities

• Lead your own project from initial cloning through to protein purification, structure determination and mechanistic dissection.
• Work on challenging multi-component membrane complexes in vitro and in cells.
• Apply structural biology techniques including cryo-electron microscopy, tomography and related methods.

Job description

Imperial College London seeks a structural biologist to lead a project on bacterial secretion systems, including Tad and Type 4 pilus systems. You will progress from cloning through purification to structure determination using cryo-EM and related methods.

Applicants should have a PhD in structural biology with a strong publication record; experience in membrane proteins and advanced microscopy is desirable. This is a full-time, fixed-term role funded by an 8-year Wellcome Trust Discovery award.