Postdoc: Engineered Protein Pores for Mitochondrial DNA Delivery

University of Cambridge; Cambridge; On-site; GBP 32,000 - 40,000; Full time

Job summary

The University of Cambridge's Medical Research Council Mitochondrial Biology Unit invites applications for a post-doctoral Research Associate to join Prof. Edmund Kunji's group in Cambridge.

This role works on engineered protein pores to deliver DNA into mitochondria as part of ARIA Precision Mitochondria, combining membrane biology, synthetic biology and genetics to advance mitochondrial gene delivery. Applicants should hold, or be close to obtaining, a PhD and have strong experience in

Qualifications

• PhD in a relevant biological discipline.
• Experience in mitochondrial, cell, RNA/DNA or molecular biology, biochemistry, membrane protein biology.
• Experience in mammalian cell culture and membrane protein complex assembly.
• Experience in mitochondrial isolation/fractionation, bioenergetics, sequencing or single-cell methods, flow cytometry, RNA/DNA biology or quantitative analysis would be highly advantageous.

Responsibilities

• Contribute to the Engineered protein pores for delivering DNA into mitochondria project within ARIA Precision Mitochondria.
• Design and screen pores to thread DNA across mitochondrial membranes and into the matrix.
• Integrate molecular and functional datasets and collaborate with ARIA partners to meet programme milestones.
• Support delivery, expression tracking with reporters, and related experimental workflows.

Skills

Mitochondrial biology

Cell biology

Molecular biology

Biochemistry

Membrane protein biology

Flow cytometry

Single-cell methods

RNA/DNA analysis

Education

PhD in a relevant biological discipline

Tools

Sequencing

Flow cytometry

Single-cell methods

Job description

The University of Cambridge's Medical Research Council Mitochondrial Biology Unit invites applications for a post-doctoral Research Associate to join Prof. Edmund Kunji's group in Cambridge.

This role works on engineered protein pores to deliver DNA into mitochondria as part of ARIA Precision Mitochondria, combining membrane biology, synthetic biology and genetics to advance mitochondrial gene delivery. Applicants should hold, or be close to obtaining, a PhD and have strong experience in