Postdoc: Antibody Engineering & Directed Evolution

Imperial College London; Greater London; On-site; GBP 45,000 - 49,000; Full time

Benefits offered by this job

43 days off per year

Generous pension scheme

Collaborative work culture

Job summary

Imperial College London in London, UK invites applications for a Postdoctoral Research Associate in Antibody Engineering and Directed Evolution to advance its antibody-engineering platform. The role sits at the interface of computational design and in vitro experiments, contributing to developability, affinity and functionality.

You will build and screen antibody and nanobody libraries, run selection campaigns, and analyze deep sequencing data to relate features to properties.

Qualifications

• PhD in Biochemistry, Molecular Biology, Chemistry, Bioengineering or a related discipline, with a focus on protein engineering.
• Practical experience in molecular biology and in vitro directed evolution (e.g., yeast or ribosome display).
• Practical experience in deep sequencing and associated data analysis.
• Knowledge of protein science and structural bioinformatics; ability to manipulate protein sequences and structural data.
• Collaborative teamwork and clear communication of complex ideas.

Responsibilities

• Strengthen the experimental pipeline by integrating high-throughput directed evolution with deep sequencing and data-driven analysis.
• Build and screen antibody and nanobody libraries; plan and run selection campaigns.
• Analyze sequencing data to relate molecular features to measured properties; feed insights into computational models.
• Collaborate with group members and external labs; publish in journals and present at meetings; supervise PhD/Master's students.

Skills

Molecular biology

Directed evolution

Data analysis

Collaborative teamwork

Communication

Interdisciplinary research

Education

PhD in Biochemistry / Molecular Biology / Chemistry / Bioengineering or related

Tools

Yeast display

Ribosome display

Structural bioinformatics

Protein sequence manipulation

Job description

Imperial College London in London, UK invites applications for a Postdoctoral Research Associate in Antibody Engineering and Directed Evolution to advance its antibody-engineering platform. The role sits at the interface of computational design and in vitro experiments, contributing to developability, affinity and functionality.

You will build and screen antibody and nanobody libraries, run selection campaigns, and analyze deep sequencing data to relate features to properties.