Postdoc: Antibody Engineering & Directed Evolution

SONICOM; Greater London; On-site; GBP 45,000 - 49,000; Full time

Benefits offered by this job

10 development days

43 days off per year

Generous pension schemes

Diverse and inclusive culture

Job summary

Imperial College London’s Sormanni Lab seeks a Postdoctoral Research Associate in Antibody Engineering and Directed Evolution to advance its antibody-engineering platform.

The role sits at the interface of computation and experiment, building libraries, running selection campaigns, and feeding sequencing data into predictive models. 12-month fixed-term contract; 35 hours per week; PhD required or near completion.

Qualifications

• A PhD in Biochemistry, Molecular Biology, Chemistry, Bioengineering or a related discipline, with a focus on protein engineering.
• Practical experience in molecular biology and in vitro directed evolution, for example yeast or ribosome display.
• Practical experience in deep sequencing and the associated data analysis.
• Knowledge of protein science and structural bioinformatics, including the ability to manipulate protein sequences and structural data.
• Collaborative teamwork skills and the ability to communicate complex scientific ideas clearly and concisely.

Responsibilities

• Strengthen the experimental pipeline by integrating high-throughput directed evolution with deep sequencing data.
• Build and screen antibody and nanobody libraries; plan selection campaigns.
• Analyze sequencing data to relate molecular features to measured properties.
• Collaborate with group members and external labs; publish in journals and present findings; supervise PhD and Masters students.

Skills

Molecular biology

Directed evolution

Deep sequencing

Protein engineering

Data analysis

Team collaboration

Education

PhD in Biochemistry, Molecular Biology, Chemistry, Bioengineering or related

Tools

Yeast display

Ribosome display

Deep sequencing analysis tools

Job description

Imperial College London’s Sormanni Lab seeks a Postdoctoral Research Associate in Antibody Engineering and Directed Evolution to advance its antibody-engineering platform.

The role sits at the interface of computation and experiment, building libraries, running selection campaigns, and feeding sequencing data into predictive models. 12-month fixed-term contract; 35 hours per week; PhD required or near completion.