PhD Studentship: Unravel U12 Intron & Autoimmune Diabetes

University of Exeter; Exeter; On-site; GBP 18,000 - 23,000; Full time

Job summary

University of Exeter invites applications for a PhD studentship exploring why certain U12-intron genes drive autoimmune diabetes. The project blends computational analysis of single-cell and patient data with experimental validation in B cells, T cells and beta cells.

You will learn to integrate multi-omics data and contribute to new drug target insights. Colleagues across data science, genetics, and immunology will train you in both in silico work (R/Python, single-cell data) and wet-lab

Qualifications

• Ideal candidate from biological, biomedical, computational, mathematical or data science backgrounds.
• Full training will be provided in unfamiliar areas.
• Experience with single-cell analysis is beneficial.

Responsibilities

• Prioritise candidate genes by analysis of public and patient data.
• Measure intron retention in patient-derived cells using established assays.
• Perform knockdown/knockout of 3–5 high-priority genes in immune cell models.
• Publish findings and contribute to thesis preparation.

Skills

Computational analysis

R/Python

Single-cell RNA-seq

Data interpretation

Education

Bachelor's degree in a relevant field

Tools

CRISPR gene editing

Digital PCR

Flow cytometry

Job description

University of Exeter invites applications for a PhD studentship exploring why certain U12-intron genes drive autoimmune diabetes. The project blends computational analysis of single-cell and patient data with experimental validation in B cells, T cells and beta cells.

You will learn to integrate multi-omics data and contribute to new drug target insights. Colleagues across data science, genetics, and immunology will train you in both in silico work (R/Python, single-cell data) and wet-lab