PhD Project: CDK Pacemaker of the Cell Cycle

Crick; Greater London; Hybrid; GBP 18,000 - 22,000; Full time

Job summary

The Francis Crick Institute in London invites applications for a PhD project exploring how CDKs regulate the cell cycle using fission yeast as a model.

The project will investigate CDK activity rise during S-phase and mitosis, nuclear localization, and chromatin’s role in CDK regulation. Training across genetics, molecular biology, cell biology, proteomics and advanced microscopy will be provided.

Responsibilities

• Investigate how CDK acts as the cell cycle pacemaker and how CDK activity rises during the cell cycle to trigger S-phase and mitosis.
• Examine coordination with cell growth and which substrates are phosphorylated and when during the cycle.
• Focus on CDK activity within the nucleus and chromatin as a platform for CDK regulation and future investigations.
• Provide training across genetics, molecular biology, cell biology, proteomics, phosphoproteomics and advanced microscopy.

Job description

The Francis Crick Institute in London invites applications for a PhD project exploring how CDKs regulate the cell cycle using fission yeast as a model.

The project will investigate CDK activity rise during S-phase and mitosis, nuclear localization, and chromatin’s role in CDK regulation. Training across genetics, molecular biology, cell biology, proteomics and advanced microscopy will be provided.