PhD: In Situ Mitochondrial Supercomplexes & Adaptation

Crick; Greater London; Hybrid; GBP 21,000 - 27,000; Full time

Job summary

The Crick-UCL Joint PhD project in partnership with Peter Rosenthal (Crick) and Amandine Marechal (UCL) combines structural biology and metabolism to study mitochondrial respiratory supercomplexes. The student will employ in situ cryo-electron tomography and metabolic assays across yeast and human cell lines, addressing how membrane organisation remodels energy production.

This PhD offers advanced training in electron cryomicroscopy, bioenergetics, and integrative structural biology within a

Qualifications

• Strong background in biochemistry, cell biology, microbiology, biophysics or structural biology.
• Experience with experimental protein biochemistry, cell culture, or cryo-EM is advantageous.
• Interest in methodological aspects and interdisciplinary collaboration.

Responsibilities

• Study how respiratory chain supercomplexes are regulated.
• Use in situ cryo-ET to visualise mitochondrial membranes.
• Integrate structural and metabolic data to link molecular mechanisms to function.
• Work across Crick Institute and UCL in an interdisciplinary team.

Skills

Mitochondrial biology

Biochemistry

Cell biology

Biophysics

Structural biology

Cryo-EM

Cryo-ET

Metabolic assays

Tools

Cryogenic electron microscopy (cryo-EM)

In situ cryo-electron tomography

Respirometry

Proteomics

Job description

The Crick-UCL Joint PhD project in partnership with Peter Rosenthal (Crick) and Amandine Marechal (UCL) combines structural biology and metabolism to study mitochondrial respiratory supercomplexes. The student will employ in situ cryo-electron tomography and metabolic assays across yeast and human cell lines, addressing how membrane organisation remodels energy production.

This PhD offers advanced training in electron cryomicroscopy, bioenergetics, and integrative structural biology within a