PhD in Peptidomimetics for Disordered Protein Interactions

University of Birmingham; Birmingham; On-site; GBP 18,000 - 23,000; Full time

Job summary

University of Birmingham is offering a PhD studentship focused on understanding and modulating protein-protein interactions (PPIs). The project will explore peptidomimetics designed to inhibit β-strand-mediated PPIs, employing N-alkylation and thioamide substitutions to enhance stability and cell uptake.

Supervisors include Professor Andy Wilson and Professor Teresa Carlomagno. The studentship is part of a collaborative program with Midlands Integrated Biosciences Training Partnership and

Responsibilities

• Develop methods to target interactions of intrinsically disordered regions engaged in PPIs.
• Systematically explore backbone amide modification across peptidomimetics designed to inhibit β-strand-mediated PPIs.
• Use N-alkylation and amide thioamide substitution to enhance cell uptake and proteolysis resistance.
• Apply automated solid-phase peptide synthesis and structural biophysical methods to study conformational ensembles.

Job description

University of Birmingham is offering a PhD studentship focused on understanding and modulating protein-protein interactions (PPIs). The project will explore peptidomimetics designed to inhibit β-strand-mediated PPIs, employing N-alkylation and thioamide substitutions to enhance stability and cell uptake.

Supervisors include Professor Andy Wilson and Professor Teresa Carlomagno. The studentship is part of a collaborative program with Midlands Integrated Biosciences Training Partnership and