Pharmacometrics Support Programmer

ICON Clinical Research; Reading; On-site; GBP 65,000 - 90,000; Full time

Benefits offered by this job

Various annual leave entitlements

Health insurance offerings

Competitive retirement planning

Global Employee Assistance Programme

Life assurance

Flexible country-specific benefits

Job summary

ICON plc is seeking a Pharmacometrics Support Programmer to join a global FSP team in Reading. You will develop and QC NONMEM PK/PD datasets, ensure data quality and regulatory readiness, and collaborate across Data Management, Statistical Programming, and Bioanalysis to drive model-informed drug development.

The role requires strong R programming expertise, SDTM/ADaM/CDISC knowledge, and a track record in PK/PD data preparation and standardisation within pharma or CRO settings.

Qualifications

• Bachelor's degree in a Life Science, Health Science, Statistics, Computer Science, IT, or related discipline.
• Minimum 6 years' experience in pharmaceutical, biotechnology, or CRO industry.
• Strong programming in R and experience developing NONMEM PK/PD datasets.
• Working knowledge of SDTM, ADaM, and CDISC standards.
• Experience supporting NONMEM file creation, quality control and submissions.

Responsibilities

• Develop and quality control NONMEM PK/PD datasets using SDTM and ADaM sources.
• Deliver accurate, complete, submission-ready datasets for modelling.
• Quality review of internally and externally produced NONMEM datasets.
• Collaborate with cross-functional teams to resolve data issues and meet timelines.
• Prepare regulatory submission datasets per pharmacometrics guidelines.
• Quality control testing of customised R packages for standardised workflows.
• Develop and maintain testing frameworks for departmental R tools and packages.
• Identify data discrepancies and opportunities for automation and efficiency.
• Contribute to pharmacometric standardisation initiatives and SOP adherence.

Skills

R programming

Data quality assurance

Education

Bachelor's degree in Life Science / Health Science / Statistics / Computer Science / IT

Tools

NONMEM

SDTM/ADaM/CDISC

Job description

Pharmacometrics Support Programmer

ICON plc is a world-leading healthcare intelligence and clinical research organization. We’re proud to foster an inclusive environment driving innovation and excellence, and we welcome you to join us on our mission to shape the future of clinical development.

About the Role

We are seeking an experienced Pharmacometrics Support Programmer to join a global FSP team. This is an opportunity for a highly analytical programmer with strong R programming expertise and experience in PK/PD data preparation to contribute to critical drug development programmes.

In this role, you will be responsible for the creation, quality control, and standardisation of NONMEM PK/PD datasets, supporting pharmacometric modelling activities across a diverse clinical portfolio. Working closely with Data Management, Statistical Programming, Statistics, Bioanalytical teams, and external partners, you will play a key role in ensuring high-quality pharmacometric data is delivered on time and to the highest regulatory standards.

Key Responsibilities

• Develop and quality control NONMEM PK/PD datasets using SDTM and ADaM data sources.

• Support pharmacometric modelling activities by delivering accurate, complete, and submission-ready datasets.

• Perform quality review of internally and externally produced NONMEM datasets.

• Collaborate with Data Management, Statistical Programming, Statistics, Clinical Pharmacology, and Bioanalytical teams to resolve data issues and ensure project timelines are met.

• Contribute to the preparation of regulatory submission projects in accordance with internal pharmacometrics guidelines.

• Conduct quality control testing of customised R packages used to standardise pharmacometric workflows.

• Develop and maintain testing frameworks and validation processes for departmental R tools and packages.

• Identify data discrepancies, process improvements, and opportunities for greater automation and efficiency.

• Actively contribute to the development and implementation of new pharmacometric standardisation initiatives.

• Ensure all deliverables comply with applicable SOPs, working instructions, regulatory requirements, and ICH-GCP guidelines.

• Maintain inspection readiness through ongoing training and adherence to quality standards.

What We're Looking For

• Bachelor's degree in a Life Science, Health Science, Statistics, Computer Science, IT, or related discipline.

• Minimum of 6 years' experience within the pharmaceutical, biotechnology, or CRO industry.

• Strong programming expertise in R.

• Experience developing and quality controlling NONMEM PK/PD datasets.

• Working knowledge of PK/PD principles and pharmacometric workflows.

• Strong understanding of SDTM, ADaM, and CDISC standards, including controlled terminology.

• Experience supporting NONMEM file creation, quality control, submissions, and standardisation activities.

• Strong attention to detail and commitment to data quality.

• Excellent written and verbal communication skills in English.

Desired Skills

• Experience reviewing and managing outsourced programming deliverables.

• Experience validating or quality controlling customised R packages.

• Demonstrated ability to identify process improvements and drive standardisation initiatives.

• Ability to work effectively across global, cross-functional teams.

Why Join Us?

• Opportunity to work within a globally recognised Clinical Pharmacology & Pharmacometrics function.

• Contribute directly to innovative drug development programmes.

• Work in a highly collaborative and scientifically driven environment.

• Be part of ongoing innovation and standardisation initiatives within pharmacometrics and clinical data science.

• Use your expertise to influence best practices and improve the efficiency and quality of pharmacometric deliverables.

If you are passionate about leveraging R programming, pharmacometrics, and data quality excellence to support drug development, we'd love to hear from you.

What ICON can offer you:

Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent.

In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.

Our benefits examples include:

• Various annual leave entitlements

• A range of health insurance offerings to suit you and your family’s needs.

• Competitive retirement planning offerings to maximize savings and plan with confidence for the years ahead.

• Global Employee Assistance Programme, LifeWorks, offering 24-hour access to a global network of over 80,000 independent specialized professionals who are there to support you and your family’s well‑being.

• Life assurance

• Flexible country‑specific optional benefits, including childcare vouchers, bike purchase schemes, discounted gym memberships, subsidized travel passes, health assessments, among others.

Visit our careers site (https://careers.iconplc.com/benefits) to read more about the benefits ICON offers.

At ICON, inclusion & belonging are fundamental to our culture and values. We’re dedicated to providing an inclusive and accessible environment for all candidates. ICON is committed to providing a workplace free of discrimination and harassment. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please let us know or submit a request here (https://careers.iconplc.com/reasonable-accommodations)