Medical Scientist

Proclinical

Oxford

On-site

GBP 85,000 - 110,000

Full time

10 days ago

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Qualifications

  • PhD in Immunology or life sciences required.
  • Minimum 5 years in immunology, inflamm biology or biologics discovery.
  • Proven leadership of scientific projects and teams.
  • Strong publication record in peer‑reviewed journals.
  • Experience with CROs and external partners.

Responsibilities

  • Lead and mentor a team of scientists and support career development.
  • Design and interpret complex pharmacology studies in vitro and in vivo.
  • Drive development of therapies in autoimmune/inflammatory programs.
  • Develop immune‑based assays for target validation and antibody discovery.
  • Collaborate with immunology, translational medicine and protein engineering experts.
  • Coordinate efficacy and pharmacology studies with CRO partners.
  • Contribute to IND‑enabling studies and due diligence activities.
  • Represent research via publications and conferences.]
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Skills

Immunology
Leadership
Mentoring
In vitro pharmacology
In vivo pharmacology
Antibody development
Translational research
Target validation
Biologics discovery
Scientific publications
Stakeholder management
CRO collaboration

Education

PhD in Immunology, Life Sciences or related discipline

Job description

Are you a highly accomplished Immunologist with a track record of leading scientific teams and driving biologics discovery programmes in autoimmune and inflammatory diseases? Proclinical is recruiting for a Principal Scientist, this position will oversee breakthrough work in inflammation and immunology. You'll play a central role in shaping therapeutic approaches, developing next‑generation biologic therapies, mentoring talented scientists, and advancing programs from target identification to preclinical development.

Working at the forefront of immunology research, you will lead and support multidisciplinary programmes spanning target identification, pharmacology, translational research and therapeutic antibody development. You will combine hands‑on scientific expertise with leadership, helping to advance novel biologic therapies from early discovery through preclinical development.

Responsibilities
  • Lead and mentor a team of laboratory‑based scientists, supporting both scientific delivery and career development
  • Design, oversee and interpret complex in vitro and in vivo pharmacology studies
  • Drive the development of novel therapeutic strategies within autoimmune and inflammatory disease programmes
  • Design and optimise immune‑based assays to support target validation and antibody discovery
  • Collaborate closely with experts across immunology, translational medicine, protein engineering, biomarkers and clinical development
  • Work with CRO partners to coordinate efficacy and pharmacology studies
  • Develop and implement endpoint and mechanism‑of‑action studies, including ex‑vivo immune profiling
  • Identify project risks, influence programme strategy and support key decision‑making discussions
  • Contribute to scientific publications, patents, regulatory documentation and due diligence activities
  • Represent research programmes through conference presentations and external scientific collaborations
Key Skills and Requirements
  • PhD in Immunology, Life Sciences or a related discipline
  • Minimum 5 years' experience within immunology, inflammation research or biologics drug discovery
  • Strong understanding of autoimmune disease biology and immune system mechanisms
  • Proven experience leading scientific projects and mentoring research teams
  • Expertise across in vitro pharmacology, assay development and immune profiling
  • Experience supporting biologics, antibody or therapeutic development programmes
  • Strong publication record with peer‑reviewed scientific contributions
  • Excellent communication, stakeholder management and leadership skills
  • Biotechnology or pharmaceutical industry experience
  • In vivo pharmacology programme leadership
  • Translational research and target validation experience
  • Experience working with CROs and external research partners
  • Contribution to IND‑enabling studies, patent applications or due diligence activities
  • Exposure to strategic portfolio or pipeline decision‑making
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