Medical Director, Immunology Programs

Sail Biomedicines; Cambridge; On-site; GBP 90,000 - 150,000; Full time

Job summary

An innovative firm is seeking a dynamic Medical Director to lead Immunology Programs, driving clinical development of groundbreaking RNA-based therapies. This pivotal role involves collaborating across teams to translate research into clinical applications, ensuring patient safety, and engaging with key opinion leaders. The ideal candidate will have a strong background in immunology, regulatory requirements, and a proven track record in clinical development. Join a forward-thinking organization committed to revolutionizing programmable medicines and making a significant impact in the field of immunotherapy.

Qualifications

• MD or MD/PhD with board certification in immunology or related specialty.
• 5-7 years of industry experience in clinical development within immunology.

Responsibilities

• Provide medical and scientific leadership for immunology clinical programs.
• Collaborate with research teams to translate preclinical concepts into clinical applications.
• Analyze clinical data to guide program decision-making.

Skills

Immunology

Clinical Development

Regulatory Requirements

Translational Immunology

Medical Monitoring

Communication Skills

Education

MD or MD/PhD

Job description

Title: Medical Director, Immunology Programs

Type: Onsite

About Sail:

Sail Biomedicines is harnessing evolutionary and artificial intelligence to revolutionize programmable medicines. Sail’s platform combines first-in-class programmable RNA technology (Endless RNATM or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is building a wealth of data, enabling unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.

The Role:

We are seeking an experienced Medical Director to lead our Immunology Programs towards clinical testing . The successful candidate will provide medical expertise and strategic direction for our immunology pipeline, from drug candidate nomination through IND and clinical development . This key leadership role will collaborate across multiple functions, including research, biomarker, regulatory , TDO , and business development to advance our existing and growing immunology pipeline of RNA-based in vivo reprogramming drug candidates towards clinical testing . This is an onsite position, with in office expectations tailored to the specific needs of the team, ensuring that responsibilities align with the team's requirements.

Responsibilities:

• Provide medical and scientific leadership for immunology clinical development programs
• Develop and implement clinical development strategies and study protocols
• Collaborate with research teams to facilitate translation of preclinical concepts into clinical applications, definition of TPP/MPP, CDP, indication selection and assessment competitive therapeutic landscape
• Author clinical sections of regulatory documents (INDs, CTAs, BLAs, etc.); serve as medical monitor for clinical trials, ensuring patient safety and data integrity; analyze and interpret clinical data to guide program decision-making
• Represent the company at scientific meetings and engage with key opinion leaders
• Contribute to publications and presentations of clinical research findings
• Partner with business development on strategic opportunities/partnership discussions and external collaborations

Qualifications:

• MD or MD/PhD with board certification in immunology, rheumatology, allergy, or relevant specialty
• Minimum 5-7 years of industry experience in clinical development within immunology or related therapeutic areas, with strong knowledge of immune-mediated diseases across autoimmune and immuno-oncology and current treatment landscapes
• Demonstrated track record of successful contribution to immunotherapy development programs; experience with clinical development of CAR cell therapy products and/or RNA-LNP products strongly preferred, but not required.
• Strong understanding of regulatory requirements for drug development
• Experience in Medical Monitoring
• Excellent knowledge of translational immunology and biomarker development
• Experience with regulatory submissions and interactions with health authorities
• Experience as a medical monitor for clinical trials and familiarity with GXP guidelines
• Strong scientific publication record and presentation skills
• Outstanding communication skills and ability to translate complex scientific concepts
• Proven ability to work effectively in cross-functional teams

Preferred Qualifications:

• Experience with both early and late-stage clinical development programs
• Background in designing innovative clinical trials
• Experience with various immunotherapeutic modalities and especially RNA, antibodies and/or cell therapies is preferred.
• Understanding of precision medicine approaches in immunology

Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.

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