Lead Scientist, Ion Channel Pharmacology & Electrophysiology

Sygnature Discovery Limited; Glasgow; On-site; GBP 90,000 - 130,000; Full time

Benefits offered by this job

25 days annual leave

Private Medical Insurance

Life Insurance

Employee Assistance Programme

Enhanced Family Friendly Policies

Sygnature Group Pension Scheme

1 paid volunteer day per year

Job summary

Sygnature Discovery Limited seeks a Principal Scientist / Associate Principal Scientist with a strong ion channel background to join its CRO team. You will provide scientific leadership across electrophysiology and pharmacology, guiding study design, execution and data interpretation for diverse client programmes.

You will mentor scientists, drive assay development and contribute to business development, shaping the growth of the electrophysiology service offering while collaborating with

Qualifications

• PhD (or equivalent) in Pharmacology, Physiology, Neuroscience, Cell Biology, or related field.
• Significant electrophysiology experience (manual or automated patch clamp).
• Strong expertise in ion channel pharmacology and assay development.
• Proven ability to lead complex scientific projects and solve technical challenges.
• Excellent communication, presentation, and client-facing skills.
• Experience mentoring or line managing scientific staff.
• Experience across GPCRs and transporters is desirable.

Responsibilities

• Provide scientific leadership across electrophysiology and pharmacology projects, including study design, execution, analysis, and interpretation.
• Act as a subject matter expert in ion channel pharmacology and electrophysiology, supporting multiple client programmes.
• Lead assay development, optimisation, validation, and troubleshooting activities.
• Work closely with multidisciplinary teams to ensure timely, high-quality project delivery.
• Drive innovation and continuous improvement through new technologies and workflows.
• Build strong client relationships through scientific discussions, data presentations, and project leadership.
• Support business development activities and contribute to the growth of the electrophysiology service offering.
• Mentor and develop scientists within the team, including line management responsibilities.

Skills

Ion channel pharmacology

Electrophysiology (patch clamp)

Project leadership

Client-facing skills

Mentoring staff

Education

PhD in Pharmacology/Physiology/Neuroscience/Cell Biology

Tools

Automated patch clamp

Manual patch clamp

Assay development

Job description

Sygnature Discovery Limited seeks a Principal Scientist / Associate Principal Scientist with a strong ion channel background to join its CRO team. You will provide scientific leadership across electrophysiology and pharmacology, guiding study design, execution and data interpretation for diverse client programmes.

You will mentor scientists, drive assay development and contribute to business development, shaping the growth of the electrophysiology service offering while collaborating with