Lead Research Fellow: Developmental Neurobiology

1000scholars; Coventry; On-site; GBP 35,000 - 46,000; Full time

Job summary

The Nelson group in the University setting seeks a Research Assistant/Research Fellow to investigate conserved gene regulatory programmes in nervous system and pancreas development. You will work with imaging of human hindbrain organoids and single-cell multiomics analysis, within a state-of-the-art building with cross-disciplinary collaboration.

Initial appointment aligns with PhD submission status; upon award, promotion to Research Fellow is expected.

Qualifications

• PhD in vertebrate developmental biology, gene regulation or related field and substantial practical experience in molecular biology.
• Full training provided for techniques as needed.

Responsibilities

• Lead an ambitious experimental genetics project using human pluripotent stem cell-derived organoids and zebrafish.
• Dissect the function and regulatory logic of highly conserved enhancers in nervous system and pancreas development.
• Combine CRISPR-mediated editing, single-cell multiomics, and phenotypic analysis of organoids.
• Perform fine-detail functional analysis of enhancer composition in vivo using zebrafish reporters.
• Manage multiple experimental lines in parallel and drive day-to-day work.

Skills

CRISPR genome editing

Stem cell differentiation

Single-cell omics

Zebrafish imaging

Data analysis

Education

PhD in vertebrate developmental biology

Tools

Organoid culture

Zebrafish husbandry

Job description

The Nelson group in the University setting seeks a Research Assistant/Research Fellow to investigate conserved gene regulatory programmes in nervous system and pancreas development. You will work with imaging of human hindbrain organoids and single-cell multiomics analysis, within a state-of-the-art building with cross-disciplinary collaboration.

Initial appointment aligns with PhD submission status; upon award, promotion to Research Fellow is expected.