Research Associate in Translational Neuroscience

1000scholars; Cambridge; Presencial; GBP 33 000 - 46 000; Tempo integral

Vantagens oferecidas por esta oferta de emprego

Mentorship

Career development

Collaborative environment

Resumo da oferta

1000scholars Cambridge invites applications for a Grade 7 Research Associate/Assistant to lead a project at CCMR, combining human stem cell biology, disease modelling, functional genomics and translational neuroscience.

The successful candidate will develop patient stem cell–derived models of progressive MS, apply CRISPR-Cas9 screens, and push discoveries toward therapies. A PhD is required; strong data analysis and collaboration are essential.

Qualificações

• PhD in cell biology, biochemistry, molecular biology or related field.
• Experience culturing human stem cells (iPSCs) and cellular engineering.
• Strong data analysis and communication skills; track record of publication.
• Experience with single-cell omics, bioinformatics, epigenomics or cell metabolism desirable.

Responsabilidades

• Lead a project at the intersection of stem cell biology and translational neuroscience.
• Develop patient stem cell-derived models of progressive MS.
• Apply functional genomics approaches to identify disease-modifying targets.

Conhecimentos

Cell biology

Biochemistry

Molecular biology

CRISPR-Cas9

Gene editing

Single-cell omics

Data analysis

Communication

Formação académica

PhD in cell biology, biochemistry, molecular biology, or related field

Ferramentas

Single-cell sequencing

Bioinformatics tools

Descrição da oferta de emprego

Applications are invited for a Research Assistant / Associate to lead a project at the intersection of human stem cell biology, disease modelling, functional genomics, and translational neuroscience. The successful candidate will develop and utilise cutting-edge patient stem cell-derived models of progressive MS to investigate the molecular mechanisms driving maladaptive glial responses, apply functional genomic approaches to identify and validate novel disease-modifying targets, and advance the translation of these discoveries towards effective therapies.

About the CCMR

The UK MS Society Cambridge Centre for Myelin Repair (CCMR) is one of the MS Society's two national Centres of Excellence. Established in 2005, it has just been renewed for a fifth five-year term (CCMR5) with the mission of accelerating the development of effective treatments for progressive MS, a condition for which no therapies currently exist to halt disability progression. Led by Professors Káradóttir, Pluchino and Coles, CCMR5 brings together six laboratories across the Department of Clinical Neurosciences and the Cambridge Stem Cell Institute, with research fellows, postdocs, clinical scientists and PhD students working across three integrated Themes: identifying the determinants of remyelination and progression (#1), validating them in next-generation human models (#2), and biomarkers of remyelination in people with MS (#3). This post sits in Theme #2, led by Professor Pluchino, and works closely with Theme #1. You will join an active community with an annual symposium, structured postdoctoral mentoring (all four CCMR4-funded postdocs went on to secure personal fellowships) and a wide international collaborator network.

About You

You will hold a PhD in cell biology, biochemistry, molecular biology, or a closely related field, with a strong background in cellular engineering and gene editing (including CRISPR-Cas9 and CRISPR-based screens) and demonstrated experience culturing human stem cells (iPSCs). You will have excellent data analysis and communication skills, a track record of scientific output, and the ability to work both independently and within a collaborative, multidisciplinary team. Experience with single-cell omics, bioinformatics, epigenomics or cell metabolism is desirable. Full criteria are set out in the Further Particulars.

This is a Grade 7 Research Associate post. Candidates who have submitted their PhD but not yet been awarded it may be appointed initially as a Research Assistant (Grade 5) and uplifted to Research Associate once the PhD is awarded.

What We Offer

Pioneering Research

The Pluchino laboratory is internationally recognised for its work on cell metabolism, stem cell biology, and neurodegeneration, with high-impact publications in Cell Stem Cell, Neuron, and Nature family journals.

A Highly Collaborative Environment

Close interactions with the Department of Clinical Neurosciences, the Cambridge Stem Cell Institute, the Clinical School and the UK Dementia Research Institute on the Cambridge Biomedical Campus.

Career Development and Mentorship

• Dedicated supervision and regular one-to-one meetings with Professor Pluchino
• Opportunity to lead high-impact projects and publish in top-tier journals
• Access to the University of Cambridge's extensive researcher development programme
• Support to develop an independent research identity, including contributing to grant applications and presenting at national and international conferences

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

£33,002 to £46,049 per annum