Lead LCMSMS Method Development in GxP Bioanalysis

Nexus Life Sciences; Stevenage; On-site; GBP 54,000 - 66,000; Full time

Benefits offered by this job

Leadership opportunity

Professional development

Collaborative culture

Innovative projects

Job summary

Nexus Life Sciences is seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards. You will lead a team of scientists, ensure GLP SOP adherence, and contribute to regulatory submissions.

The role combines technical leadership with people management, overseeing method development, troubleshooting, and regulatory support. A strong background in HPLC/UPLC/LCMSMS and DOE is required.

Qualifications

• Must have a degree in Biochemistry, Biomedical Science, or a related field.
• Minimum 4+ years in a GxP laboratory with at least 2+ years in management.
• Expertise in HPLC/UPLC/LCMSMS and chromatography data systems.
• Strong problem-solving, troubleshooting, and leadership abilities.
• Familiarity with protein precipitation, SPE, and liquid–liquid extraction in sample prep.
• Understanding of GLP, SOPs, and regulatory requirements.
• Excellent communication and organizational skills.

Responsibilities

• Lead method development and validation as a subject matter expert.
• Optimize extraction techniques, chromatography methods, and LC columns.
• Manage and mentor the Method Development & Validation team.
• Ensure GLP compliance, SOP adherence, and international guidelines.
• Troubleshoot analytical methods and implement improvements.
• Oversee cost-effective lab operations and consumables spend.
• Write and approve Methods of Analysis and transfer methods to teams.
• Support regulatory submissions and respond to queries.
• Conduct investigations, implement CAPAs, and drive continuous improvement.
• Prepare, review, and ensure GLP SOP adherence.
• Lead team meetings and staff development sessions.

Skills

HPLC

UPLC

LCMSMS

Method development

Validation

Leadership

Communication

Regulatory knowledge

Problem solving

DOE

Minitab

MassLynx

Empower

Education

Biochemistry / Biomedical Science degree

Tools

Empower

MassLynx

Minitab

Job description

Nexus Life Sciences is seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards. You will lead a team of scientists, ensure GLP SOP adherence, and contribute to regulatory submissions.

The role combines technical leadership with people management, overseeing method development, troubleshooting, and regulatory support. A strong background in HPLC/UPLC/LCMSMS and DOE is required.