Lead LC-MS Protein Characterisation Scientist

Lonza, Inc.; Slough; On-site; Confidential; Full time

Benefits offered by this job

Agile career

Inclusive workplace

Lead scientific projects

Competitive compensation

Global benefits

Job summary

Lonza in Slough is recruiting a Lead Analytical Scientist to drive analytical characterisation of therapeutic proteins. Based in Slough, you will lead complex scientific projects, develop and troubleshoot advanced analytical methods, and apply mass spectrometry and protein characterisation to support product characterisation and regulatory studies.

Please note: practical mass spectrometry experience is essential. Candidates with hands-on LC-MS/MS experience are required.

Qualifications

• Hands-on mass spectrometry experience is essential.
• Experience developing, validating, optimising and troubleshooting analytical methods for proteins, including LC-based techniques such as RP and SEC.
• Experience using LC‑MS/MS to characterise protein primary structure, size, charge variants and post‑translational modifications.

Responsibilities

• Lead complex analytical projects from planning through execution, ensuring objectives, timelines, quality and regulatory expectations are met.
• Develop, optimise and troubleshoot analytical methods for therapeutic proteins, with a particular focus on LC-MS/MS‑based characterisation, alongside RP, SEC.
• Apply mass spectrometry to investigate protein structure, molecular size, charge variants and post‑translational modifications, interpreting complex datasets to generate scientifically robust conclusions.
• Provide technical leadership, training and practical support to scientists and system users, particularly in LC-MS techniques.
• Perform and technically review analytical testing supporting product characterisation, reference standards and biochemical comparability studies, ensuring results are scientifically sound and appropriately documented.
• Collaborate with internal teams and external customers, communicating scientific findings clearly and demonstrating Lonza's expertise in analytical characterisation.
• Drive continuous improvement by developing more efficient approaches, supporting non‑standard molecules, contributing to root‑cause investigations and maintaining analytical capabilities in line with industry and regulatory expectations.

Skills

Mass spectrometry

LC-MS/MS

Protein characterisation

Mentoring

Project leadership

Tools

RP chromatography

SEC

icIEF

Job description

Lonza in Slough is recruiting a Lead Analytical Scientist to drive analytical characterisation of therapeutic proteins. Based in Slough, you will lead complex scientific projects, develop and troubleshoot advanced analytical methods, and apply mass spectrometry and protein characterisation to support product characterisation and regulatory studies.

Please note: practical mass spectrometry experience is essential. Candidates with hands-on LC-MS/MS experience are required.