Lead In Silico Biologics Design & AI Discovery

ASTRAZENECA UK LIMITED; Hartford; Hybrid; GBP 90,000 - 150,000; Full time

Job summary

AstraZeneca UK Limited seeks an in silico project leader to own computational strategy across multiple therapeutic programs, shaping design hypotheses and key decisions. You will co-develop scalable structural analytics workflows with discovery and data science colleagues to accelerate candidate design and create reproducible insights.

You will lead end-to-end data capability integrating structural, sequence and experimental data to actionable recommendations, evaluating next-gen computational

Qualifications

• PhD in relevant field (e.g. Structural Biology, Computer Science, Bioinformatics, Physics and Mathematics) is required.
• Experience with computational structural biology and data analysis methods.

Responsibilities

• Own the computational strategy for multiple programs and inform design hypotheses.
• Co-develop scalable, reproducible structural analytics workflows with discovery and data science colleagues.
• Lead end-to-end data capability connecting structural, sequence and experimental data to actionable recommendations.
• Evaluate and deploy new computational tools and platforms for biologics discovery and design.
• Drive AI-driven design and optimisation for proteins, VHHs and antibodies.
• Engage in external collaborations to translate science into practical tools and impact.

Job description

AstraZeneca UK Limited seeks an in silico project leader to own computational strategy across multiple therapeutic programs, shaping design hypotheses and key decisions. You will co-develop scalable structural analytics workflows with discovery and data science colleagues to accelerate candidate design and create reproducible insights.

You will lead end-to-end data capability integrating structural, sequence and experimental data to actionable recommendations, evaluating next-gen computational