Lead Genome-Scale Modelling for Engineered RBCs

University of Bristol; West of England; On-site; GBP 40,000 - 50,000; Full time

Job summary

University of Bristol’s School of Engineering Mathematics and Technology invites applications for a Postdoctoral Research Associate role in genome-scale metabolic modelling for red blood cell engineering. Lead modelling within the Aerobic Engineering Biology programme, collaborating with Northwestern University and industrial partners to design engineered red blood cells.

You will develop and apply genome-scale models, integrate engineered circuits, analyse omics data, and work with experimental

Qualifications

• PhD or near completion in mathematics, bioengineering, engineering biology, bioinformatics, biotechnology or closely related discipline.
• Expertise in genome-scale metabolic modelling.
• Strong mathematical modelling and programming skills.
• Experience working collaboratively with experimental scientists.
• Excellent analytical and problem-solving skills.
• Strong written and verbal communication skills, including the ability to publish high-quality research.
• Ability to work independently while contributing in a multidisciplinary team and meet deadlines.

Responsibilities

• Develop and refine genome-scale metabolic models of reticulocytes and mature red blood cells.
• Build mathematical models of engineered gene and enzyme circuits and integrate into broader metabolic frameworks.
• Analyse metabolomics and other datasets to investigate metabolic changes during maturation and engineering.
• Collaborate with experimental researchers to validate models and optimise circuit design.
• Work with collaborators and industry partners to advance project objectives.
• Maintain records of code, models and outputs for reproducible research.
• Contribute to progress reports and publish research findings.

Skills

Genome-scale metabolic modelling

Mathematical modelling

Programming

Collaborative research

Publish research

Education

PhD or near completion in relevant field

Job description

University of Bristol’s School of Engineering Mathematics and Technology invites applications for a Postdoctoral Research Associate role in genome-scale metabolic modelling for red blood cell engineering. Lead modelling within the Aerobic Engineering Biology programme, collaborating with Northwestern University and industrial partners to design engineered red blood cells.

You will develop and apply genome-scale models, integrate engineered circuits, analyse omics data, and work with experimental