Lead Analytical Chemistry Scientist - Build & Scale Lab

Xyme Ltd

Oxford

On-site

GBP 90,000 - 120,000

Full time

7 days ago

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Job summary

Xyme Ltd is seeking a Principal Scientist, Analytical Chemistry to establish and lead the company’s analytical capabilities in Oxford. You will select instrumentation, build in-house lab capabilities within 6 months, and maintain CRO partnerships for overflow capacity.

The role blends strategic planning with hands-on lab work to support biocatalysis and protein design. You will guide method development and data interpretation, lead a small team, and collaborate with AI-driven design workflows to

Qualifications

8+ years of relevant experience in research or industry settings.
Proven ability to develop and validate analytical methods for quantification of substrates, products and intermediates.
Experience establishing analytical capabilities or laboratories, including instrument selection and method implementation.

Responsibilities

Establish and shape Xyme's analytical chemistry function, defining strategy and building capabilities.
Develop and validate analytical methods for small molecule quantification and reaction monitoring.
Implement intact protein MS techniques for protein QC and peptide synthesis platform to produce high-quality peptides.
Manage relationships with CROs to deliver high-quality data and maintain capacity.
Lead hands-on analytical work to support biocatalysis and protein characterisation programs.
Mentor and develop a small team of analytical scientists and ensure instrument uptime.