In Vivo Gene Therapy Scientist — CNS & Ocular Models

Barrington James; Greater London; On-site; GBP 55,000 - 90,000; Full time

Job summary

Barrington James is assisting a growing research organisation in recruiting an experienced Research Scientist to support preclinical and early clinical gene therapy programmes. The role focuses on in vivo studies in mice, with ocular/retinal and brain/CNS experience highly valued.

You will establish and execute in vivo studies from preclinical stages through early clinical development, contributing to a dynamic pipeline and cross-functional collaboration across R&D, quality, and regulatory teams.

Qualifications

• Strong hands-on in vivo experience using mice.
• Experience with technically challenging or specialised in vivo procedures.
• Experience within gene therapy, ideally AAV-based gene therapy.
• Experience writing study reports, SOPs, and protocols.

Responsibilities

• Design, establish and execute in vivo gene therapy studies in mice.
• Take studies from setup through execution, data interpretation and reporting.
• Develop and optimise in vivo potency and safety assays for gene therapy programmes.
• Work with ocular/retinal, brain or CNS models, including specialised procedures.
• Support development and evaluation of AAV-based gene therapies and readouts.
• Troubleshoot studies and develop new experimental workflows.
• Analyze and interpret preclinical data to progress programmes to the clinic.
• Produce high-quality study reports, SOPs and work instructions.
• Contribute to establishment of new in vivo models and lab processes.
• Collaborate across R&D, quality, regulatory and compliance functions.

Skills

In vivo experience

Mice handling

Ocular/retinal experience

Brain/CNS neuroscience

Study design

Data interpretation

Scientific reporting

Tools

AAV vector systems

Job description

Barrington James is assisting a growing research organisation in recruiting an experienced Research Scientist to support preclinical and early clinical gene therapy programmes. The role focuses on in vivo studies in mice, with ocular/retinal and brain/CNS experience highly valued.

You will establish and execute in vivo studies from preclinical stages through early clinical development, contributing to a dynamic pipeline and cross-functional collaboration across R&D, quality, and regulatory teams.