In Situ Mitochondrial Supercomplexes: Structural Adaptation

THE FRANCIS CRICK INSTITUTE LIMITED; Greater London; Vor Ort; GBP 18.000 - 23.000; Vollzeit

Zusammenfassung

The Francis Crick Institute in London invites applications for a joint Crick-UCL PhD project led by Peter Rosenthal and Amandine Marechal on in situ structural biology of cellular adaptation.

The project addresses how mitochondrial respiratory complexes remodel and how membrane organisation reshapes metabolism, using cryo-electron tomography, respirometry, and molecular perturbation in yeast and human cell lines.

Qualifikationen

• Background in biochemistry, cell biology, microbiology, biophysics or structural biology.
• Interest in mitochondrial biology and cellular adaptation to stress.

Aufgaben

• Engage in multidisciplinary training across Crick and collaborating labs.
• Investigate remodeling of mitochondrial respiratory complexes and membrane organisation.

Kenntnisse

Biochemistry

Cell biology

Biophysics

Structural biology

Ausbildung

BSc in a relevant field

Strong scientific background

Tools

Cryo-EM

Cryo-electron tomography

Respirometry

Jobbeschreibung

The Francis Crick Institute in London invites applications for a joint Crick-UCL PhD project led by Peter Rosenthal and Amandine Marechal on in situ structural biology of cellular adaptation.

The project addresses how mitochondrial respiratory complexes remodel and how membrane organisation reshapes metabolism, using cryo-electron tomography, respirometry, and molecular perturbation in yeast and human cell lines.