Higher or Senior Scientific Officer

THE INSTITUTE OF CANCER RESEARCH; London; On-site; GBP 39,000 - 71,000; Full time

Job summary

A leading cancer research institute seeks a Higher or Senior Scientific Officer to lead molecular genomics and single cell sequencing studies focused on colorectal cancer evolution. The role involves advanced NGS experiments and collaboration within a multidisciplinary team dedicated to cancer research. The successful candidate will have a PhD in molecular biology and expertise in single cell technologies, contributing to impactful research in a dynamic environment.

Benefits

Dynamic and supportive research environment

Access to state-of-the-art facilities

Professional development opportunities

Collaboration with leading researchers

Competitive salary and pension

Qualifications

• PhD in molecular biology or relevant area required.
• Ability to perform advanced NGS experiments and single cell analysis.
• Proven expertise in advanced NGS technologies.

Responsibilities

• Lead experimental wet-lab work to generate molecular genomics data.
• Undertake research into colorectal cancer development.
• Conduct single cell sequencing studies.

Skills

Advanced NGS experiments

Single cell sequencing

Good communication skills

Education

PhD in molecular biology

Undergraduate degree in biological or quantitative subject

Tools

RNA-seq

DNA-seq

scRNA-seq

scATAC-seq

Spatial transcriptomics

Job description

Salary Range: £39,805 - £49,023 per annum

Duration of Contract: Fixed Term for 2 years

Hours per week: 35 hours (Full Time)

Location: Sutton

Under the guidance of Prof Trevor Graham, we are seeking to recruit a Higher or Senior Scientific Officer to lead molecular genomics and single cell sequencing studies of cancer evolution. The principal duty of the post will be to undertake research into the evolutionary dynamics that underpin colorectal cancer development and response to treatment. The post holder will lead experimental wet-lab work to generate molecular genomics data, particularly single cell data, from patient material, cell lines, organoids, and other sample types.

About you

The successful candidate must have:

• PhD in molecular biology or a relevant area; undergraduate degree in biological or quantitative subject.
• Ability to perform advanced NGS experiments for cancer genome analysis.
• Experience with single cell/nuclei dissociation, sorting, and NGS analysis in cell lines and/or patient biopsies.
• Proven expertise in advanced NGS technologies, including RNA-seq, DNA-seq, and single-cell sequencing.
• Hands-on experience with single-cell technologies such as scRNA-seq, scATAC-seq, or spatial transcriptomics.
• Good communication skills and ability to interact effectively with team members.

Department/Directorate Information

The Centre for Evolution and Cancer (CEC), within the Division of Cancer Biology, is a multidisciplinary centre comprising around 50 staff dedicated to understanding cancer evolution and leveraging this knowledge for translational benefit. Our interests span early detection through to treatment of metastatic disease. The CEC combines expertise in evolutionary theory, computational biology, and bioinformatics with cutting-edge research in cell and molecular biology, fostering a stimulating interdisciplinary environment for innovative cancer research.

The Genomics and Evolutionary Dynamics team integrates molecular and cellular biology with mathematical and computational modelling to study malignancy evolution. Our focus areas include early detection in the gastrointestinal tract, colorectal cancer evolution and treatment response, and pan-cancer genomics. We conduct fundamental research into human biology in health and disease, aiming to translate findings into improved clinical care.

What we offer

• A dynamic and supportive research environment
• Access to state-of-the-art facilities and professional development opportunities
• Collaboration with leading researchers
• Competitive salary and pension

We encourage all applicants to access the attached job pack for more detailed information. For informal discussions, please contact Prof Trevor Graham at [e-mail].

About The Institute of Cancer Research

Why work for us?

As a staff member, you'll have access to a range of benefits.

The Institute of Cancer Research, London, is a leading cancer research institute with a history spanning over 100 years. More information about working at the ICR can be found on our website.

We welcome applications from all candidates worldwide. We particularly encourage applications from British applicants from black and ethnic minority backgrounds, as they are underrepresented within the ICR and in STEM roles nationally.