Global DMPK Lead: PK/ADME Strategy & Translation

UCB - Union Chimique Belge; Slough; On-site; GBP 120,000 - 180,000; Full time

Job summary

UCB - Union Chimique Belge in the United Kingdom seeks a senior DMPK Lead to provide scientific leadership across discovery and development. You will define DMPK strategies, interpret PK/PD and translational studies, and influence candidate selection and risk mitigation.

This global role requires collaboration with toxicology, clinical pharmacology and translational sciences to advance patient-focused therapies.

Qualifications

• PhD in Pharmaceutics, Pharmacology, DMPK, or related discipline.
• Significant industrial DMPK experience across discovery and development.
• Strong expertise in ADME, PK studies, and human PK prediction.
• Knowledge of regulatory requirements and submission processes.
• Experience with modelling and simulation (PBPK preferred).
• Proven ability to work effectively in global, cross-functional teams.

Responsibilities

• Lead DMPK strategy across discovery and clinical development programs.
• Design and interpret PK, PK/PD, toxicokinetic, ADME, and translational studies.
• Influence compound design, candidate selection, and risk mitigation.
• Predict human pharmacokinetics, dose, and drug–drug interaction risks.
• Contribute to modelling and simulation, including PBPK activities.
• Author DMPK sections for regulatory submissions and internal documents.
• Serve as DMPK expert for due diligence evaluations of external opportunities.
• Provide scientific mentoring and coaching to junior staff.

Skills

DMPK leadership

PK/PD expertise

PBPK modelling

Cross-functional collaboration

Education

PhD in Pharmaceutics/Pharmacology/DMPK

Tools

PBPK Modelling

Job description

UCB - Union Chimique Belge in the United Kingdom seeks a senior DMPK Lead to provide scientific leadership across discovery and development. You will define DMPK strategies, interpret PK/PD and translational studies, and influence candidate selection and risk mitigation.

This global role requires collaboration with toxicology, clinical pharmacology and translational sciences to advance patient-focused therapies.